A growing body ol evidence suggests oxidative stress as part of the toxicity mechanism ol methyl-mercury (MeHg) in cell cultures and animal models and so justifies the use ol natural antioxidants as therapeutic alternatives. This research examines the effect of an aqueous extract from the marine seaweed Halimeda incrassata (Hi) against the oxidative stress induced by MeHg on in vitro and in vivo models. In GTI-7 mouse hypothalamic cell cultures, the extract of Hi increased cell viability and reduced ROS production after 24-h exposure to MeHgCI. Wistar rats, acutely intoxicated with MeHgCI, had reduced levels of serum and brain thiobarbituric reactive substances when treated with the Hi extract. Similarly, animals exposed to repeated doses of MeHgCI were protected by the seaweed extract from variations in body weight, food consumption and the appearance of neurological effects. This research supports the notion that oxidative stress is directly involved in MeHg intoxication, so that natural antioxidants, particularly those in the extract of Hi, can be useful therapeutic alternatives.
|Original language||English (US)|
|Number of pages||5|
|Journal||Veterinary and Human Toxicology|
|State||Published - Feb 1 2004|
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis