Antinuclear antibody testing: Methods, indications, and interpretation

Eric L. Greidinger; Robert W. Hoffman

doi:10.1309/VUB9-0VTP-MEWV-3W0F

Antinuclear antibody testing: Methods, indications, and interpretation

Eric L. Greidinger, Robert W. Hoffman

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Antinuclear antibody (ANA) testing is commonly used in the assessment of patients who may have an autoimmune disease. This tutorial review discusses the methods currently available to perform ANA testing, the indications for ANA tests, and the interpretation of ANA results. While ANA testing can provide helpful diagnostic information, it typically does not provide information regarding disease activity. Given the significant rate of positive ANA results in the general population, a positive ANA test should not be over-interpreted.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	Laboratory Medicine
Volume	34
Issue number	2
DOIs	https://doi.org/10.1309/VUB9-0VTP-MEWV-3W0F
State	Published - Feb 1 2003
Externally published	Yes

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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abstract = "Antinuclear antibody (ANA) testing is commonly used in the assessment of patients who may have an autoimmune disease. This tutorial review discusses the methods currently available to perform ANA testing, the indications for ANA tests, and the interpretation of ANA results. While ANA testing can provide helpful diagnostic information, it typically does not provide information regarding disease activity. Given the significant rate of positive ANA results in the general population, a positive ANA test should not be over-interpreted.",

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AB - Antinuclear antibody (ANA) testing is commonly used in the assessment of patients who may have an autoimmune disease. This tutorial review discusses the methods currently available to perform ANA testing, the indications for ANA tests, and the interpretation of ANA results. While ANA testing can provide helpful diagnostic information, it typically does not provide information regarding disease activity. Given the significant rate of positive ANA results in the general population, a positive ANA test should not be over-interpreted.

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