Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat

Peter W. Kalivas, Barbara A. Gau, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the central nucleus of the amygdala (AC) produced a significant increase in the nociceptive threshold of the rat, while injections into tissue adjacent to the AC were generally ineffective. Antinociception following intra-AC injection of NT occurred at an ED50 dose of 2.4 μg NT, and was significantly lower than the ED50 dose observed when NT was given into the lateral ventricles (93.2 μg NT). Lesions of the stria terminalis totally abolished the antinociceptive effect of intra-AC administration of NT, indicating that AC efferent or afferent fibers within the stria terminalis are necessary for the observed increase in nociceptive threshold.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalBrain Research
Volume243
Issue number2
DOIs
StatePublished - Jul 15 1982
Externally publishedYes

Keywords

  • antinociception
  • central amygdaloid nucleus
  • hot plate
  • lesion
  • microinjection
  • neurotensin
  • stria terminalis

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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