Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States: Comparison of 1981 with 1982

G. J. Cuchural, F. P. Tally, N. V. Jacobus, S. L. Gorbach, K. Aldridge, Timothy Cleary, S. M. Finegold, G. Hill, P. Iannini, J. P. O'Keefe

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A susceptibility survey of 537 strains of the Bacteroides fragilis group from eight centers in the United States was continued at the Tufts New England Medical Center in 1982. The results were compared with those of 755 organisms analyzed in 1981. Nine antimicrobial agents were tested by an agar dilution method. The respective percentages of resistance for 1981 and 1982 were as follows (%): cefoxitin, 8 and 10; moxalactam, 22 and 12; cefotaxime, 54 and 48; cefoperazone, 57 and 54; piperacillin, 12 and 7; clindamycin, 6 and 3; metronidazole, 0 and 0; chloramphenicol, 0 and 0; and tetracycline, 63 and 59. Regional differences in resistance rates were found. Declines in resistance to moxalactam, piperacillin, and clindamycin were noted at the participating hospitals. An outbreak of cefoxitin resistance was noted at the Tufts New England Medical Center, where the rate increased from 14 to 30%. The various species of the B. fragilis group had differing patterns of resistance; B. fragilis was the most susceptible species. Significant cross resistance among the beta-lactam agents was found. These data indicate the need to determine the susceptibility patterns of the B. fragilis group organisms within each hospital.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume26
Issue number2
StatePublished - Sep 27 1984
Externally publishedYes

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Bacteroides fragilis
Moxalactam
Cefoxitin
Piperacillin
New England
Clindamycin
beta-Lactam Resistance
Cefoperazone
Cefotaxime
Metronidazole
Chloramphenicol
Anti-Infective Agents
Tetracycline
Agar
Disease Outbreaks

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Cuchural, G. J., Tally, F. P., Jacobus, N. V., Gorbach, S. L., Aldridge, K., Cleary, T., ... O'Keefe, J. P. (1984). Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States: Comparison of 1981 with 1982. Antimicrobial Agents and Chemotherapy, 26(2), 145-148.

Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States : Comparison of 1981 with 1982. / Cuchural, G. J.; Tally, F. P.; Jacobus, N. V.; Gorbach, S. L.; Aldridge, K.; Cleary, Timothy; Finegold, S. M.; Hill, G.; Iannini, P.; O'Keefe, J. P.

In: Antimicrobial Agents and Chemotherapy, Vol. 26, No. 2, 27.09.1984, p. 145-148.

Research output: Contribution to journalArticle

Cuchural, GJ, Tally, FP, Jacobus, NV, Gorbach, SL, Aldridge, K, Cleary, T, Finegold, SM, Hill, G, Iannini, P & O'Keefe, JP 1984, 'Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States: Comparison of 1981 with 1982', Antimicrobial Agents and Chemotherapy, vol. 26, no. 2, pp. 145-148.
Cuchural, G. J. ; Tally, F. P. ; Jacobus, N. V. ; Gorbach, S. L. ; Aldridge, K. ; Cleary, Timothy ; Finegold, S. M. ; Hill, G. ; Iannini, P. ; O'Keefe, J. P. / Antimicrobial susceptibilities of 1,292 isolates of the Bacteroides fragilis group in the United States : Comparison of 1981 with 1982. In: Antimicrobial Agents and Chemotherapy. 1984 ; Vol. 26, No. 2. pp. 145-148.
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