Abstract
To identify virological and immunological correlates of microbial-specific immune reconstitution in children with advanced human immunodeficiency virus (HIV) infection, Candida- and tetanus-specific lymphocyte proliferation was measured in 165 children initiating a new highly active antiretroviral therapy (HAART) regimen. During the study, the proportions of children with immunity to Candida and tetanus increased from 53% to 66% and 19% to 22%, respectively. Tetanus immunity was associated with an HIV load ≤400 RNA copies/mL and with Candida immunity. At the end of the study, 23% of the patients with baseline negative lymphocyte proliferation had tetanus immunity, and 65% had Candida immunity. Reconstitution of tetanus immunity correlated with lower end-of-study HIV loads and activated CD8 + cell percentages and higher baseline and in-study CD4 + cell percentages, but not with a gain of CD4 + cells. Reconstitution of Candida immunity showed similar trends. In conclusion, children with advanced HIV infection receiving HAART reconstituted Candida immunity more readily than they did tetanus immunity, suggesting a role for antigen reexposure. Additional factors for immune reconstitution were low HIV load, high CD4 + cell percentages, and low levels of activated CD8 + cells.
| Original language | English |
|---|---|
| Pages (from-to) | 107-114 |
| Number of pages | 8 |
| Journal | Clinical Infectious Diseases |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy. / Weinberg, Adriana; Pahwa, Savita G; Oyomopito, Rebecca; Carey, Vincent J.; Zimmer, Bonnie; Mofenson, Lynne; Kovacs, Andrea; Burchett, Sandra K.
In: Clinical Infectious Diseases, Vol. 39, No. 1, 01.07.2004, p. 107-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy
AU - Weinberg, Adriana
AU - Pahwa, Savita G
AU - Oyomopito, Rebecca
AU - Carey, Vincent J.
AU - Zimmer, Bonnie
AU - Mofenson, Lynne
AU - Kovacs, Andrea
AU - Burchett, Sandra K.
PY - 2004/7/1
Y1 - 2004/7/1
N2 - To identify virological and immunological correlates of microbial-specific immune reconstitution in children with advanced human immunodeficiency virus (HIV) infection, Candida- and tetanus-specific lymphocyte proliferation was measured in 165 children initiating a new highly active antiretroviral therapy (HAART) regimen. During the study, the proportions of children with immunity to Candida and tetanus increased from 53% to 66% and 19% to 22%, respectively. Tetanus immunity was associated with an HIV load ≤400 RNA copies/mL and with Candida immunity. At the end of the study, 23% of the patients with baseline negative lymphocyte proliferation had tetanus immunity, and 65% had Candida immunity. Reconstitution of tetanus immunity correlated with lower end-of-study HIV loads and activated CD8 + cell percentages and higher baseline and in-study CD4 + cell percentages, but not with a gain of CD4 + cells. Reconstitution of Candida immunity showed similar trends. In conclusion, children with advanced HIV infection receiving HAART reconstituted Candida immunity more readily than they did tetanus immunity, suggesting a role for antigen reexposure. Additional factors for immune reconstitution were low HIV load, high CD4 + cell percentages, and low levels of activated CD8 + cells.
AB - To identify virological and immunological correlates of microbial-specific immune reconstitution in children with advanced human immunodeficiency virus (HIV) infection, Candida- and tetanus-specific lymphocyte proliferation was measured in 165 children initiating a new highly active antiretroviral therapy (HAART) regimen. During the study, the proportions of children with immunity to Candida and tetanus increased from 53% to 66% and 19% to 22%, respectively. Tetanus immunity was associated with an HIV load ≤400 RNA copies/mL and with Candida immunity. At the end of the study, 23% of the patients with baseline negative lymphocyte proliferation had tetanus immunity, and 65% had Candida immunity. Reconstitution of tetanus immunity correlated with lower end-of-study HIV loads and activated CD8 + cell percentages and higher baseline and in-study CD4 + cell percentages, but not with a gain of CD4 + cells. Reconstitution of Candida immunity showed similar trends. In conclusion, children with advanced HIV infection receiving HAART reconstituted Candida immunity more readily than they did tetanus immunity, suggesting a role for antigen reexposure. Additional factors for immune reconstitution were low HIV load, high CD4 + cell percentages, and low levels of activated CD8 + cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=3042759284&partnerID=8YFLogxK
U2 - 10.1086/420931
DO - 10.1086/420931
M3 - Article
C2 - 15206061
AN - SCOPUS:3042759284
VL - 39
SP - 107
EP - 114
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 1
ER -