Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy

Adriana Weinberg, Savita G Pahwa, Rebecca Oyomopito, Vincent J. Carey, Bonnie Zimmer, Lynne Mofenson, Andrea Kovacs, Sandra K. Burchett

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To identify virological and immunological correlates of microbial-specific immune reconstitution in children with advanced human immunodeficiency virus (HIV) infection, Candida- and tetanus-specific lymphocyte proliferation was measured in 165 children initiating a new highly active antiretroviral therapy (HAART) regimen. During the study, the proportions of children with immunity to Candida and tetanus increased from 53% to 66% and 19% to 22%, respectively. Tetanus immunity was associated with an HIV load ≤400 RNA copies/mL and with Candida immunity. At the end of the study, 23% of the patients with baseline negative lymphocyte proliferation had tetanus immunity, and 65% had Candida immunity. Reconstitution of tetanus immunity correlated with lower end-of-study HIV loads and activated CD8 + cell percentages and higher baseline and in-study CD4 + cell percentages, but not with a gain of CD4 + cells. Reconstitution of Candida immunity showed similar trends. In conclusion, children with advanced HIV infection receiving HAART reconstituted Candida immunity more readily than they did tetanus immunity, suggesting a role for antigen reexposure. Additional factors for immune reconstitution were low HIV load, high CD4 + cell percentages, and low levels of activated CD8 + cells.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalClinical Infectious Diseases
Volume39
Issue number1
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

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Highly Active Antiretroviral Therapy
Virus Diseases
Immunity
Tetanus
HIV
Candida
Lymphocytes
Immunologic Factors
RNA
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy. / Weinberg, Adriana; Pahwa, Savita G; Oyomopito, Rebecca; Carey, Vincent J.; Zimmer, Bonnie; Mofenson, Lynne; Kovacs, Andrea; Burchett, Sandra K.

In: Clinical Infectious Diseases, Vol. 39, No. 1, 01.07.2004, p. 107-114.

Research output: Contribution to journalArticle

Weinberg, Adriana ; Pahwa, Savita G ; Oyomopito, Rebecca ; Carey, Vincent J. ; Zimmer, Bonnie ; Mofenson, Lynne ; Kovacs, Andrea ; Burchett, Sandra K. / Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy. In: Clinical Infectious Diseases. 2004 ; Vol. 39, No. 1. pp. 107-114.
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