Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension

T. F. Luscher, P. M. Vanhoutte, Leopoldo Raij

Research output: Contribution to journalArticle

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Abstract

Endothelium-dependent responses are impaired in various models of hypertension. The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on a high or low sodium diet. The rats were given either a diet containing 8% NaCl or 0.1% NaCl for 8 weeks or a diet containing 8% NaCl and a combination of reserpine, hydrochlorothiazide, and hydralazine for 8 or 2 weeks. DS on the 8% NaCl diet developed hypertension, while the other rats did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed hypertension in DS and lowered blood pressure in DR on the 8% NaCl diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, acetylcholine, adenosine 5'-diphosphate, and thrombin caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% NaCl compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, sodium nitroprusside. These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of cardiovascular complications in patients with hypertension.

Original languageEnglish
JournalHypertension
Volume9
Issue number6 II SUPPL.
StatePublished - Jan 1 1987
Externally publishedYes

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Antihypertensive Agents
Endothelium
Salts
Hypertension
Diet
Therapeutics
Inbred Dahl Rats
Sodium-Restricted Diet
Hydralazine
Hydrochlorothiazide
Reserpine
Nitroprusside
Thrombin
Adenosine Diphosphate
Acetylcholine
Blood Pressure

ASJC Scopus subject areas

  • Internal Medicine

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Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. / Luscher, T. F.; Vanhoutte, P. M.; Raij, Leopoldo.

In: Hypertension, Vol. 9, No. 6 II SUPPL., 01.01.1987.

Research output: Contribution to journalArticle

Luscher, T. F. ; Vanhoutte, P. M. ; Raij, Leopoldo. / Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. In: Hypertension. 1987 ; Vol. 9, No. 6 II SUPPL.
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