Antihypertensive effects of oxprenolol and propranolol

Barry J Materson, Ulrich F. Michael, James R. Oster, Eliseo C. Perez-Stable, Alba Hernandez, Mary Smith

Research output: Contribution to journalArticle

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Abstract

The antihypertensive effects of the beta blockers oxprenolol and propranolol were compared in a randomized double-blind study of patients with standing diastolic pressures (SDP) exceeding 99 mm Hg when receiving hydrochlorothiazide alone. After 3 wk of hydrochlorothiazide with placebo, the latter was replaced with oxprenolol (n = 12) or propranolol (n = 12), 20 mg three times daily. Beta blocker was increased subsequently to 40 and 80 mg three times daily if SDP exceeded 89 ruin Hg. Nine oxprenolol and 7 propranolol subjects were hospitalized for 24-hr monitoring. With oxprenolol, standing pressure declined from 135 ± 2 (SE)/104 ± I mm Hg to 128 ± 3190 ± 2. SDP declined to under 91 mm Hg in 7 of 12 subjects, and to from 91 to 95 in 3 subjects. With propranolol, findings were 138 ± 31106 ± 2 to 123 ± 3189 ± 3; in 7 of 12 to less than 91 mm Hg and from 91 to 95 in 4 subjects. Decrements in supine and SDP were slightly (4 mm Hg) greater for propranolol than for oxprenolol. Both drugs gave similar 24-hr blood pressure control. We conclude that oxprenolol and propranolol used to supplement hydrochlorothiazide provide comparable reductions in blood pressure and smooth control over a 24-hr period in most patients with hypertension.

Original languageEnglish
Pages (from-to)142-151
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume20
Issue number2
StatePublished - Aug 1 1976

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Oxprenolol
Propranolol
Antihypertensive Agents
Blood Pressure
Hydrochlorothiazide
Double-Blind Method
Placebos
Hypertension
Pressure
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Materson, B. J., Michael, U. F., Oster, J. R., Perez-Stable, E. C., Hernandez, A., & Smith, M. (1976). Antihypertensive effects of oxprenolol and propranolol. Clinical Pharmacology and Therapeutics, 20(2), 142-151.

Antihypertensive effects of oxprenolol and propranolol. / Materson, Barry J; Michael, Ulrich F.; Oster, James R.; Perez-Stable, Eliseo C.; Hernandez, Alba; Smith, Mary.

In: Clinical Pharmacology and Therapeutics, Vol. 20, No. 2, 01.08.1976, p. 142-151.

Research output: Contribution to journalArticle

Materson, BJ, Michael, UF, Oster, JR, Perez-Stable, EC, Hernandez, A & Smith, M 1976, 'Antihypertensive effects of oxprenolol and propranolol', Clinical Pharmacology and Therapeutics, vol. 20, no. 2, pp. 142-151.
Materson BJ, Michael UF, Oster JR, Perez-Stable EC, Hernandez A, Smith M. Antihypertensive effects of oxprenolol and propranolol. Clinical Pharmacology and Therapeutics. 1976 Aug 1;20(2):142-151.
Materson, Barry J ; Michael, Ulrich F. ; Oster, James R. ; Perez-Stable, Eliseo C. ; Hernandez, Alba ; Smith, Mary. / Antihypertensive effects of oxprenolol and propranolol. In: Clinical Pharmacology and Therapeutics. 1976 ; Vol. 20, No. 2. pp. 142-151.
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