Antihypertensive drug therapy does not perturb the circadian blood pressure pattern

Barry J Materson, Richard A Preston

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The literature was reviewed to determine whether failure of older antihypertensive drugs to suppress the early morning increase of blood pressure was responsible, in part, for the less than satisfactory rate of reduction in cardiovascular mortality rates in the United States. The authors found that neither the old nor the new antihypertensive drugs altered the 24- hour blood pressure curve pattern, although long-acting drugs did show continued effect at the end of the 24-hour period when compared with placebo. The efficacy of these drugs most likely lies with their blood pressure lowering and other ancillary effects and not with pattern changes. More importantly, examination of new data (1989) shows that the rate of decline in death due to diseases of the heart has exceeded that for cerebrovascular diseases. Our overall health care effort may be more successful than we thought.

Original languageEnglish
Pages (from-to)627-629
Number of pages3
JournalJournal of Clinical Pharmacology
Volume32
Issue number7
StatePublished - Jan 1 1992

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Antihypertensive Agents
Blood Pressure
Drug Therapy
Cerebrovascular Disorders
Pharmaceutical Preparations
Heart Diseases
Placebos
Delivery of Health Care
Mortality

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Antihypertensive drug therapy does not perturb the circadian blood pressure pattern. / Materson, Barry J; Preston, Richard A.

In: Journal of Clinical Pharmacology, Vol. 32, No. 7, 01.01.1992, p. 627-629.

Research output: Contribution to journalArticle

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