Antifungal activity of plumericin and isoplumericin

Dharmendra Singh, Umakant Sharma, Parveen Kumar, Yogesh K. Gupta, M. P. Dobhal, Sarman Singh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1567-1568
Number of pages2
JournalNatural Product Communications
Volume6
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Keywords

  • Candidiasis
  • Cryptococcosis
  • Isoplumericin
  • Plumeria bicolor
  • Plumericin

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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