Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain

Markus Heilig, Claes Wahlestedt, Rolf Ekman, Erik Widerlöv

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Rats were given imipramine or zimeldine orally for three weeks and the brain levels of neuropeptide Y-like immunoreactivity (NPY-LI) were measured. The concentration of NPY-LI in frontal cortical tissue was elevated by 40 and 60%, respectively. Imipramine increased the concentration of NPY-LI in the hypothalamus by 65% while zimeldine was without effect. The concentration of NPY-LI in the parietal cortex was unaffected by either of the drugs. These observations support the hypothesis that NPY might be involved in the pathophysiology of depressive illness.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalEuropean Journal of Pharmacology
Volume147
Issue number3
DOIs
StatePublished - Mar 15 1988
Externally publishedYes

Keywords

  • (Rat)
  • Cortex
  • Imipramine
  • Neuropeptide Y-like immunoreactivity (NPY-LI)
  • Zimeldine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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