Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain

Markus Heilig, Claes R Wahlestedt, Rolf Ekman, Erik Widerlöv

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Rats were given imipramine or zimeldine orally for three weeks and the brain levels of neuropeptide Y-like immunoreactivity (NPY-LI) were measured. The concentration of NPY-LI in frontal cortical tissue was elevated by 40 and 60%, respectively. Imipramine increased the concentration of NPY-LI in the hypothalamus by 65% while zimeldine was without effect. The concentration of NPY-LI in the parietal cortex was unaffected by either of the drugs. These observations support the hypothesis that NPY might be involved in the pathophysiology of depressive illness.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalEuropean Journal of Pharmacology
Volume147
Issue number3
DOIs
StatePublished - Mar 15 1988
Externally publishedYes

Fingerprint

Neuropeptide Y
Antidepressive Agents
Zimeldine
Brain
Imipramine
Parietal Lobe
Hypothalamus
Pharmaceutical Preparations

Keywords

  • (Rat)
  • Cortex
  • Imipramine
  • Neuropeptide Y-like immunoreactivity (NPY-LI)
  • Zimeldine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. / Heilig, Markus; Wahlestedt, Claes R; Ekman, Rolf; Widerlöv, Erik.

In: European Journal of Pharmacology, Vol. 147, No. 3, 15.03.1988, p. 465-467.

Research output: Contribution to journalArticle

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