Anticonvulsants in the treatment of bipolar disorder

P. E. Keck, S. L. McElroy, Charles Nemeroff

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

In the last decade, a proliferation of research has emerged concerning the use of somatic treatments with anticonvulsant properties, e.g., carbamazepine, valproate, clonazepam, oxcarbazepine, and electroconvulsive therapy (ECT), for patients with bipolar disorder. A sufficient number of controlled studies have been conducted to allow critical review of the evidence supporting the efficacy of these treatments for acute bipolar manic and depressive episodes, as well as for the prevention of subsequent episodes. Further research is needed to establish the prophylactic efficacy of anticonvulsants as maintenance therapies and, perhaps most importantly, to provide clinical and biological predictors of response.

Original languageEnglish
Pages (from-to)395-405
Number of pages11
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume4
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes

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Bipolar Disorder
Anticonvulsants
Clonazepam
Electroconvulsive Therapy
Carbamazepine
Valproic Acid
Research
Therapeutics
oxcarbazepine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Anticonvulsants in the treatment of bipolar disorder. / Keck, P. E.; McElroy, S. L.; Nemeroff, Charles.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 4, No. 4, 01.01.1992, p. 395-405.

Research output: Contribution to journalArticle

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