Anticholinergics and antacid tablets versus cimetidine in the treatment of active duodenal ulcers

J. C. Meeroff, M. Meeroff, A. Serchio

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A 4-week comparative open prospective randomized trial of cimetidine versus a combination of a low dose of antacids plus a low dose of an anticholinergic antimuscarinic agent was conducted in 50 outpatients with endoscopically proven active duodenal ulcers. Ulcer healing occurred in 17 of 25 patients receiving cimetidine (68%) and in 19 of 25 patients receiving the combination of antacids plus anticholinergics (76%). Patients with unhealed ulcers after the 4-week trial period were crossed-over to the other treatment and ulcers healed in 5 of 8 patients switched to the combination of antacids plus anticholinergics and in 3 of 6 patients switched to cimetidine after 3 weeks of treatment. Minor side effects were reported in 8 patients receiving cimetidine and in 7 receiving the combination of antacids plus anticholinergics. Eight of 14 patients (57%) with unhealed ulcers became asymptomatic during the last week of the trial, which indicates that freedom from ulcer pain is a poor predictor of healing. It is concluded that the treatment based on the combination of a low dose of antacids and a low dose of anticholinergic antimuscarinic agents is as effective as cimetidine for enhancing healing of acute duodenal ulcers.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume29
Issue number6 I
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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