TY - JOUR
T1 - Anticardiolipin antibodies in acute myeloid leukemia
T2 - Prevalence and clinical significance
AU - Lossos, Izidore S.
AU - Bogomolski-Yahalom, Vered
AU - Matzner, Yaacov
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - This prospective study was designed to explore the prevalence and the clinical and prognostic significance of anticardiolipin (ACL) antibodies in patients with acute myeloid leukemia (AML). The study includes 37 consecutive AML patients >15 years old without previous history of thromboembolism, recurrent fetal loss, or autoimmune disease and with no evidence of infection at the time of enrollment. ACL antibodies were found in 25 patients (68%). None of the patients had high positive titers; 8 had moderately positive while 17 had low positive ACL antibody titers. ACL antibody positivity did not predict response to chemotherapy and was not correlated with age, gender, FAB class, platelet and white blood cell counts at presentation, and the risk of thromboembolism. ACL antibody titers did correlate, however, with AML activity in the majority of patients (93%) during 4-19 months of follow up. These results demonstrate a high prevalence of ACL antibodies in AML patients and suggest that serum ACL antibodies may be a useful adjunct in predicting relapse and documenting disease activity and therapy response.
AB - This prospective study was designed to explore the prevalence and the clinical and prognostic significance of anticardiolipin (ACL) antibodies in patients with acute myeloid leukemia (AML). The study includes 37 consecutive AML patients >15 years old without previous history of thromboembolism, recurrent fetal loss, or autoimmune disease and with no evidence of infection at the time of enrollment. ACL antibodies were found in 25 patients (68%). None of the patients had high positive titers; 8 had moderately positive while 17 had low positive ACL antibody titers. ACL antibody positivity did not predict response to chemotherapy and was not correlated with age, gender, FAB class, platelet and white blood cell counts at presentation, and the risk of thromboembolism. ACL antibody titers did correlate, however, with AML activity in the majority of patients (93%) during 4-19 months of follow up. These results demonstrate a high prevalence of ACL antibodies in AML patients and suggest that serum ACL antibodies may be a useful adjunct in predicting relapse and documenting disease activity and therapy response.
KW - Acute myeloid leukemia
KW - Anticardiolipin antibodies
KW - Lupus anticoagulant
UR - http://www.scopus.com/inward/record.url?scp=0031906206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031906206&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8652(199802)57:2<139::AID-AJH8>3.0.CO;2-X
DO - 10.1002/(SICI)1096-8652(199802)57:2<139::AID-AJH8>3.0.CO;2-X
M3 - Article
C2 - 9462546
AN - SCOPUS:0031906206
VL - 57
SP - 139
EP - 143
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 2
ER -