Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye

Samuel D. Bernal, Theodore J. Lampidis, Robert M. Mcisaac, Lan Bo Chen

Research output: Contribution to journalArticle

212 Scopus citations

Abstract

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalScience
Volume222
Issue number4620
DOIs
StatePublished - 1983

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