Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.

S. Sakamoto, H. Kudo, K. Kuwa, S. Suzuki, T. Kato, T. Kawasaki, T. Nakayama, Noriyuki Kasahara, R. Okamoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalAmerican Journal of Chinese Medicine
Volume19
Issue number3-4
StatePublished - 1991
Externally publishedYes

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1,2-Dimethylhydrazine
Herbal Medicine
Fluorouracil
Colonic Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Dimethylhydrazines
Thymidylate Synthase
DNA
Enzymes
Carcinogens
Prescriptions
Weight Loss
Body Weight
juzentaihoto
pyrimidine

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats. / Sakamoto, S.; Kudo, H.; Kuwa, K.; Suzuki, S.; Kato, T.; Kawasaki, T.; Nakayama, T.; Kasahara, Noriyuki; Okamoto, R.

In: American Journal of Chinese Medicine, Vol. 19, No. 3-4, 1991, p. 233-241.

Research output: Contribution to journalArticle

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AU - Kudo, H.

AU - Kuwa, K.

AU - Suzuki, S.

AU - Kato, T.

AU - Kawasaki, T.

AU - Nakayama, T.

AU - Kasahara, Noriyuki

AU - Okamoto, R.

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