Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.

S. Sakamoto, H. Kudo, K. Kuwa, S. Suzuki, T. Kato, T. Kawasaki, T. Nakayama, N. Kasahara, R. Okamoto

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalThe American journal of Chinese medicine
Volume19
Issue number3-4
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Complementary and alternative medicine

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