Antibody-independent binding of complement component C1q by Legionella pneumophila

C. S. Mintz, P. I. Arnold, W. Johnson, D. R. Schultz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Incubation of Legionella pneumophila Philadelphia 1 in normal human serum depleted of either classical-pathway component C1q or alternative-pathway component factor B resulted in activation of the complement system. Experiments focused on the role of the classical pathway in complement activation revealed that legionellae bound C1q independently of antibody. Purified preparations of L. pneumophila major outer membrane protein but not serogroup 1 lipopolysaccharide hound C1q independently of antibody. This suggests that antibody-independent binding of C1q by L. pneumophila can result in activation of the classical pathway in normal human serum and that major outer membrane protein may be a C1q acceptor on the L. pneumophila cell surface.

Original languageEnglish
Pages (from-to)4939-4943
Number of pages5
JournalInfection and Immunity
Volume63
Issue number12
StatePublished - Jan 1 1995
Externally publishedYes

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Complement C1q
Legionella pneumophila
Antibodies
Classical Complement Pathway
Legionella
Complement Activation
Serum
Lipopolysaccharides
Membrane Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Mintz, C. S., Arnold, P. I., Johnson, W., & Schultz, D. R. (1995). Antibody-independent binding of complement component C1q by Legionella pneumophila. Infection and Immunity, 63(12), 4939-4943.

Antibody-independent binding of complement component C1q by Legionella pneumophila. / Mintz, C. S.; Arnold, P. I.; Johnson, W.; Schultz, D. R.

In: Infection and Immunity, Vol. 63, No. 12, 01.01.1995, p. 4939-4943.

Research output: Contribution to journalArticle

Mintz, CS, Arnold, PI, Johnson, W & Schultz, DR 1995, 'Antibody-independent binding of complement component C1q by Legionella pneumophila', Infection and Immunity, vol. 63, no. 12, pp. 4939-4943.
Mintz CS, Arnold PI, Johnson W, Schultz DR. Antibody-independent binding of complement component C1q by Legionella pneumophila. Infection and Immunity. 1995 Jan 1;63(12):4939-4943.
Mintz, C. S. ; Arnold, P. I. ; Johnson, W. ; Schultz, D. R. / Antibody-independent binding of complement component C1q by Legionella pneumophila. In: Infection and Immunity. 1995 ; Vol. 63, No. 12. pp. 4939-4943.
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