Antibody-independent binding of complement component C1q by Legionella pneumophila

C. S. Mintz, P. I. Arnold, W. Johnson, D. R. Schultz

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Incubation of Legionella pneumophila Philadelphia 1 in normal human serum depleted of either classical-pathway component C1q or alternative-pathway component factor B resulted in activation of the complement system. Experiments focused on the role of the classical pathway in complement activation revealed that legionellae bound C1q independently of antibody. Purified preparations of L. pneumophila major outer membrane protein but not serogroup 1 lipopolysaccharide hound C1q independently of antibody. This suggests that antibody-independent binding of C1q by L. pneumophila can result in activation of the classical pathway in normal human serum and that major outer membrane protein may be a C1q acceptor on the L. pneumophila cell surface.

Original languageEnglish (US)
Pages (from-to)4939-4943
Number of pages5
JournalInfection and immunity
Issue number12
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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