Abstract
The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (T(G)) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (T(M)) displayed no ADCC activity T(G)-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 407-416 |
| Number of pages | 10 |
| Journal | Immunology |
| Volume | 39 |
| Issue number | 3 |
| State | Published - Jan 1 1980 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Katz, P., & Fauci, A. S. (1980). Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: Killing of human erythrocytes and autologous lymphoid cells. Immunology, 39(3), 407-416.