Abstract
The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (T(G)) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (T(M)) displayed no ADCC activity T(G)-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.
| Original language | English |
|---|---|
| Pages (from-to) | 407-416 |
| Number of pages | 10 |
| Journal | Immunology |
| Volume | 39 |
| Issue number | 3 |
| State | Published - Jan 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
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Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes : Killing of human erythrocytes and autologous lymphoid cells. / Katz, P.; Fauci, A. S.
In: Immunology, Vol. 39, No. 3, 01.01.1980, p. 407-416.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes
T2 - Killing of human erythrocytes and autologous lymphoid cells
AU - Katz, P.
AU - Fauci, A. S.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (T(G)) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (T(M)) displayed no ADCC activity T(G)-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.
AB - The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (T(G)) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (T(M)) displayed no ADCC activity T(G)-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018849714&partnerID=8YFLogxK
M3 - Article
C2 - 6969215
AN - SCOPUS:0018849714
VL - 39
SP - 407
EP - 416
JO - Immunology
JF - Immunology
SN - 0019-2805
IS - 3
ER -