Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: Killing of human erythrocytes and autologous lymphoid cells

P. Katz, A. S. Fauci

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (T(G)) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (T(M)) displayed no ADCC activity T(G)-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalImmunology
Volume39
Issue number3
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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