Antibodies to Native DNA in Systemic Lupus Erythematosus: A Technique of Rapid and Quantitative Determination

Nicholas M. Kredich, Jay S. Skyler, Linda J. Foote

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

The nitrocellulose membrane technique for detecting DNA protein complexes was used to demonstrate antibodies to native DNA in the sera of patients with systemic lupus erythematosus (SLE). Such antibodies were found in 19 of 21 patients with active SLE, in 10 of 12 patients with inactive SLE, and in 3 of 217 controls. This rapidly performed assay is easily quantified and can be useful in the diagnosis and management of patients with SLE.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalArchives of internal medicine
Volume131
Issue number5
DOIs
StatePublished - May 1973
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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