Antibodies to Native DNA in Systemic Lupus Erythematosus: A Technique of Rapid and Quantitative Determination

Nicholas M. Kredich; Jay S. Skyler; Linda J. Foote

doi:10.1001/archinte.1973.00320110023002

Antibodies to Native DNA in Systemic Lupus Erythematosus: A Technique of Rapid and Quantitative Determination

Nicholas M. Kredich, Jay S. Skyler, Linda J. Foote

Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The nitrocellulose membrane technique for detecting DNA protein complexes was used to demonstrate antibodies to native DNA in the sera of patients with systemic lupus erythematosus (SLE). Such antibodies were found in 19 of 21 patients with active SLE, in 10 of 12 patients with inactive SLE, and in 3 of 217 controls. This rapidly performed assay is easily quantified and can be useful in the diagnosis and management of patients with SLE.

Original language	English (US)
Pages (from-to)	639-644
Number of pages	6
Journal	Archives of internal medicine
Volume	131
Issue number	5
DOIs	https://doi.org/10.1001/archinte.1973.00320110023002
State	Published - May 1973

ASJC Scopus subject areas

Internal Medicine

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abstract = "The nitrocellulose membrane technique for detecting DNA protein complexes was used to demonstrate antibodies to native DNA in the sera of patients with systemic lupus erythematosus (SLE). Such antibodies were found in 19 of 21 patients with active SLE, in 10 of 12 patients with inactive SLE, and in 3 of 217 controls. This rapidly performed assay is easily quantified and can be useful in the diagnosis and management of patients with SLE.",

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