Antibodies to cardiac conducting tissue in progressive systemic sclerosis

U. Volta, A. S. Villecco, F. B. Bianchi, C. Varotti, F. Cassani, M. Lenzi, S. Veronesi, Antonella Tosti, E. Pisi

Research output: Contribution to journalArticle

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Abstract

Cardiac conducting tissue antibodies (CCTA) were detected, using indirect immunofluorescence, 8 (25%) out of 32 sera from patients with progressive systemic sclerosis (PSS) and in 39 (35%) out of 110 with rheumatoid arthritis (RA). Conduction abnormalities, namely right bundle branch block, were present in 19 (59%) of the PSS patients and in 37 (32%) of the RA cases. No significant correlation was found between the prevalence of CCTA and conduction abnormalities in PSS patients, while this was present in RA patients (p < 0.001). CCTA were always negative in 18 patients with systemic lupus erythematosus and were found in one out of 8 cases with Sjogren's syndrome, also positive for rheumatoid factor without clinical RA. These data suggest that CCTA are evoked when involvement of cardiac conducting tissue (as in RA) or working myocardium (as in PSS) is present. Whether CCTA should be mainly regarded as an expression of the immunological derangement underlying these pathological conditions or whether they are secondary to myocardial tissue damage, must still be clarified.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalClinical and Experimental Rheumatology
Volume3
Issue number2
StatePublished - Aug 28 1985
Externally publishedYes

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Diffuse Scleroderma
Rheumatoid Arthritis
Antibodies
Bundle-Branch Block
Rheumatoid Factor
Sjogren's Syndrome
Indirect Fluorescent Antibody Technique
Systemic Lupus Erythematosus
Myocardium
Serum

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Volta, U., Villecco, A. S., Bianchi, F. B., Varotti, C., Cassani, F., Lenzi, M., ... Pisi, E. (1985). Antibodies to cardiac conducting tissue in progressive systemic sclerosis. Clinical and Experimental Rheumatology, 3(2), 131-135.

Antibodies to cardiac conducting tissue in progressive systemic sclerosis. / Volta, U.; Villecco, A. S.; Bianchi, F. B.; Varotti, C.; Cassani, F.; Lenzi, M.; Veronesi, S.; Tosti, Antonella; Pisi, E.

In: Clinical and Experimental Rheumatology, Vol. 3, No. 2, 28.08.1985, p. 131-135.

Research output: Contribution to journalArticle

Volta, U, Villecco, AS, Bianchi, FB, Varotti, C, Cassani, F, Lenzi, M, Veronesi, S, Tosti, A & Pisi, E 1985, 'Antibodies to cardiac conducting tissue in progressive systemic sclerosis', Clinical and Experimental Rheumatology, vol. 3, no. 2, pp. 131-135.
Volta U, Villecco AS, Bianchi FB, Varotti C, Cassani F, Lenzi M et al. Antibodies to cardiac conducting tissue in progressive systemic sclerosis. Clinical and Experimental Rheumatology. 1985 Aug 28;3(2):131-135.
Volta, U. ; Villecco, A. S. ; Bianchi, F. B. ; Varotti, C. ; Cassani, F. ; Lenzi, M. ; Veronesi, S. ; Tosti, Antonella ; Pisi, E. / Antibodies to cardiac conducting tissue in progressive systemic sclerosis. In: Clinical and Experimental Rheumatology. 1985 ; Vol. 3, No. 2. pp. 131-135.
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