Antibiotic therapy for Bacillus species infections

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We reviewed 36 cases of culture-proven Bacillus species ocular infections occurring between September 1974 and December 1989. Kirby-Bauer disk sensitivities were available in 34 of the 36 cases (95%). All Bacillus species isolates were sensitive to the aminoglycoside antibiotics (N = 34) and to vancomycin hydrochloride (N = 32); resistance to clindamycin was found in four of 18 (22%) of tested isolates. Although B. cereus was uniformly sensitive to these antibiotics, resistance to clindamycin occurred in four cases in the non-B. cereus group. The microbroth dilution technique confirmed the Kirby-Bauer data. The aminoglycosides were uniformly effective, but the cephalosporins (first, second, and third generation drugs) were consistently ineffective against B. cereus and varied from sensitive to moderately sensitive for the non-B. cereus isolates. Our microbiologic laboratory findings suggest that vancomycin hydrochloride in combination with an aminoglycoside ensures more consistent antibiotic coverage of Bacillus species ocular infections.

Original languageEnglish
Pages (from-to)683-687
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume110
Issue number6
StatePublished - Dec 1 1990

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Aminoglycosides
Bacillus
Eye Infections
Clindamycin
Vancomycin
Anti-Bacterial Agents
Infection
Indicator Dilution Techniques
Cephalosporins
Microbial Drug Resistance
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Antibiotic therapy for Bacillus species infections. / Kervick, G. N.; Flynn, Harry W; Alfonso, Eduardo C; Miller, Darlene.

In: American Journal of Ophthalmology, Vol. 110, No. 6, 01.12.1990, p. 683-687.

Research output: Contribution to journalArticle

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