Antibiotic prophylaxis: Different practice patterns within and outside the United States

Stephen Schwartz, Andrzej Grzybowski, Harry W Flynn

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Endophthalmitis remains a rare but important cause of visual loss. Prophylaxis strategies are important to reduce rates of endophthalmitis after cataract surgery, intravitreal injection, and other procedures. There is substantial variability between the US and the rest of the world. During cataract surgery, intracameral antibiotics are commonly used in many nations, especially in Europe, but are less commonly used in the US. A randomized clinical trial from the European Society of Cataract and Refractive Surgeons reported an approximately fivefold reduction in endophthalmitis rates associated with intracameral cefuroxime but these results are controversial. There are no randomized clinical trials regarding endophthalmitis associated with intravitreal injection. Topical antibiotics are commonly used in many nations, but are less commonly used in the US. At this time, there is no global consensus and it appears unlikely that additional major clinical trials will conclusively define the optimal endophthalmitis prophylaxis techniques.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalClinical Ophthalmology
Volume10
DOIs
StatePublished - Jan 28 2016

Fingerprint

Endophthalmitis
Antibiotic Prophylaxis
Intravitreal Injections
Cataract
Randomized Controlled Trials
Anti-Bacterial Agents
Cefuroxime
Clinical Trials

Keywords

  • Cataract surgery
  • Endophthalmitis
  • Intracameral antibiotic
  • Intravitreal injection
  • Prophylaxis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Antibiotic prophylaxis : Different practice patterns within and outside the United States. / Schwartz, Stephen; Grzybowski, Andrzej; Flynn, Harry W.

In: Clinical Ophthalmology, Vol. 10, 28.01.2016, p. 251-256.

Research output: Contribution to journalArticle

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