Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont, Sam W. Wiesel, Carl T. Brighton, Richard H. Rothman

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

Original languageEnglish (US)
Pages (from-to)254-256
Number of pages3
JournalSPINE
Volume12
Issue number3
DOIs
StatePublished - Apr 1987

Keywords

  • Antibiotic penetration
  • Nucleus pulposus
  • Serum level

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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    Eismont, F. J., Wiesel, S. W., Brighton, C. T., & Rothman, R. H. (1987). Antibiotic penetration into rabbit nucleus pulposus. SPINE, 12(3), 254-256. https://doi.org/10.1097/00007632-198704000-00011