Abstract
A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 254-256 |
| Number of pages | 3 |
| Journal | SPINE |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1987 |
Keywords
- Antibiotic penetration
- Nucleus pulposus
- Serum level
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Clinical Neurology
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Cite this
Eismont, F. J., Wiesel, S. W., Brighton, C. T., & Rothman, R. H. (1987). Antibiotic penetration into rabbit nucleus pulposus. SPINE, 12(3), 254-256. https://doi.org/10.1097/00007632-198704000-00011