Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont, Sam W. Wiesel, Carl T. Brighton, Richard H. Rothman

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

Original languageEnglish (US)
Pages (from-to)254-256
Number of pages3
Issue number3
StatePublished - Apr 1987


  • Antibiotic penetration
  • Nucleus pulposus
  • Serum level

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


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