Abstract
A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.
Original language | English (US) |
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Pages (from-to) | 254-256 |
Number of pages | 3 |
Journal | SPINE |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Apr 1987 |
Keywords
- Antibiotic penetration
- Nucleus pulposus
- Serum level
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Clinical Neurology