Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont; Sam W. Wiesel; Carl T. Brighton; Richard H. Rothman

doi:10.1097/00007632-198704000-00011

Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont, Sam W. Wiesel, Carl T. Brighton, Richard H. Rothman

Orthopaedics

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

Original language	English (US)
Pages (from-to)	254-256
Number of pages	3
Journal	SPINE
Volume	12
Issue number	3
DOIs	https://doi.org/10.1097/00007632-198704000-00011
State	Published - Apr 1987

Keywords

Antibiotic penetration
Nucleus pulposus
Serum level

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Clinical Neurology

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title = "Antibiotic penetration into rabbit nucleus pulposus",

abstract = "A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.",

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author = "Eismont, {Frank J.} and Wiesel, {Sam W.} and Brighton, {Carl T.} and Rothman, {Richard H.}",

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AU - Eismont, Frank J.

AU - Wiesel, Sam W.

AU - Brighton, Carl T.

AU - Rothman, Richard H.

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AB - A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

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KW - Serum level

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