Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont; Sam W. Wiesel; Carl T. Brighton; Richard H. Rothman

doi:10.1097/00007632-198704000-00011

Antibiotic penetration into rabbit nucleus pulposus

Frank J. Eismont, Sam W. Wiesel, Carl T. Brighton, Richard H. Rothman

Orthopaedics

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

Original language	English (US)
Pages (from-to)	254-256
Number of pages	3
Journal	SPINE
Volume	12
Issue number	3
DOIs	https://doi.org/10.1097/00007632-198704000-00011
State	Published - Apr 1987

Keywords

Antibiotic penetration
Nucleus pulposus
Serum level

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Clinical Neurology

Access to Document

10.1097/00007632-198704000-00011

Cite this

@article{4ab29f03ab51424b8c87a5286decc828,

title = "Antibiotic penetration into rabbit nucleus pulposus",

abstract = "A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.",

keywords = "Antibiotic penetration, Nucleus pulposus, Serum level",

author = "Eismont, {Frank J.} and Wiesel, {Sam W.} and Brighton, {Carl T.} and Rothman, {Richard H.}",

year = "1987",

month = apr,

doi = "10.1097/00007632-198704000-00011",

language = "English (US)",

volume = "12",

pages = "254--256",

journal = "Spine",

issn = "0362-2436",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Antibiotic penetration into rabbit nucleus pulposus

AU - Eismont, Frank J.

AU - Wiesel, Sam W.

AU - Brighton, Carl T.

AU - Rothman, Richard H.

PY - 1987/4

Y1 - 1987/4

N2 - A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

AB - A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.

KW - Antibiotic penetration

KW - Nucleus pulposus

KW - Serum level

UR - http://www.scopus.com/inward/record.url?scp=0023175949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023175949&partnerID=8YFLogxK

U2 - 10.1097/00007632-198704000-00011

DO - 10.1097/00007632-198704000-00011

M3 - Article

C2 - 3589822

AN - SCOPUS:0023175949

VL - 12

SP - 254

EP - 256

JO - Spine

JF - Spine

SN - 0362-2436

IS - 3

ER -

Antibiotic penetration into rabbit nucleus pulposus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this