Antiangiogenic properties of gold nanoparticles

Priyabrata Mukherjee, Resham Bhattacharya, Ping Wang, Ling Wang, Sujit Basu, Janice A. Nagy, Anthony Atala, Debabrata Mukhopadhyay, Shay Soker

Research output: Contribution to journalArticle

323 Citations (Scopus)

Abstract

Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothetial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non-heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.

Original languageEnglish
Pages (from-to)3530-3534
Number of pages5
JournalClinical Cancer Research
Volume11
Issue number9
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Gold
Nanoparticles
Vascular Endothelial Growth Factor A
Cell Proliferation
Vascular Endothelial Growth Factor Receptor
Fibroblast Growth Factor 2
Mitogens
Epidermal Growth Factor
Heparin
Permeability
Intercellular Signaling Peptides and Proteins
Glycoproteins
Endothelial Cells
Fibroblasts
Phosphorylation
Calcium
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mukherjee, P., Bhattacharya, R., Wang, P., Wang, L., Basu, S., Nagy, J. A., ... Soker, S. (2005). Antiangiogenic properties of gold nanoparticles. Clinical Cancer Research, 11(9), 3530-3534. https://doi.org/10.1158/1078-0432.CCR-04-2482

Antiangiogenic properties of gold nanoparticles. / Mukherjee, Priyabrata; Bhattacharya, Resham; Wang, Ping; Wang, Ling; Basu, Sujit; Nagy, Janice A.; Atala, Anthony; Mukhopadhyay, Debabrata; Soker, Shay.

In: Clinical Cancer Research, Vol. 11, No. 9, 01.05.2005, p. 3530-3534.

Research output: Contribution to journalArticle

Mukherjee, P, Bhattacharya, R, Wang, P, Wang, L, Basu, S, Nagy, JA, Atala, A, Mukhopadhyay, D & Soker, S 2005, 'Antiangiogenic properties of gold nanoparticles', Clinical Cancer Research, vol. 11, no. 9, pp. 3530-3534. https://doi.org/10.1158/1078-0432.CCR-04-2482
Mukherjee P, Bhattacharya R, Wang P, Wang L, Basu S, Nagy JA et al. Antiangiogenic properties of gold nanoparticles. Clinical Cancer Research. 2005 May 1;11(9):3530-3534. https://doi.org/10.1158/1078-0432.CCR-04-2482
Mukherjee, Priyabrata ; Bhattacharya, Resham ; Wang, Ping ; Wang, Ling ; Basu, Sujit ; Nagy, Janice A. ; Atala, Anthony ; Mukhopadhyay, Debabrata ; Soker, Shay. / Antiangiogenic properties of gold nanoparticles. In: Clinical Cancer Research. 2005 ; Vol. 11, No. 9. pp. 3530-3534.
@article{a1118ff68b2341caa5bd4166330653f0,
title = "Antiangiogenic properties of gold nanoparticles",
abstract = "Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothetial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non-heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.",
author = "Priyabrata Mukherjee and Resham Bhattacharya and Ping Wang and Ling Wang and Sujit Basu and Nagy, {Janice A.} and Anthony Atala and Debabrata Mukhopadhyay and Shay Soker",
year = "2005",
month = "5",
day = "1",
doi = "10.1158/1078-0432.CCR-04-2482",
language = "English",
volume = "11",
pages = "3530--3534",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "9",

}

TY - JOUR

T1 - Antiangiogenic properties of gold nanoparticles

AU - Mukherjee, Priyabrata

AU - Bhattacharya, Resham

AU - Wang, Ping

AU - Wang, Ling

AU - Basu, Sujit

AU - Nagy, Janice A.

AU - Atala, Anthony

AU - Mukhopadhyay, Debabrata

AU - Soker, Shay

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothetial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non-heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.

AB - Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothetial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non-heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.

UR - http://www.scopus.com/inward/record.url?scp=18244396366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18244396366&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-04-2482

DO - 10.1158/1078-0432.CCR-04-2482

M3 - Article

C2 - 15867256

AN - SCOPUS:18244396366

VL - 11

SP - 3530

EP - 3534

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 9

ER -