In 1989, Ferrara and Henzel (1) isolated a diffusible protein from bovine pituitary follicular cells that showed cell-specific mitogenic activity for vascular endothelium. They named this protein vascular endothelial growth factor (VEGF). Further research showed that VEGF was in fact Michelson’s factor X, which was the postulated diffusible angiogenesis factor (2). As discussed in Chapter 5, VEGF was then shown to have a major role in choroidal neovascularization (CNV) (3,4).
|Original language||English (US)|
|Title of host publication||Age-Related Macular Degeneration, Second Edition|
|Number of pages||10|
|State||Published - Jan 1 2007|
ASJC Scopus subject areas