Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells

C. G. Ziegler, M. Ullrich, A. V. Schally, R. Bergmann, J. Pietzsch, L. Gebauer, K. Gondek, N. Qin, K. Pacak, M. Ehrhart-Bornstein, G. Eisenhofer, S. R. Bornstein

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Pheochromocytoma is a rare but potentially lethal chromaffin cell tumor with currently no effective treatment. Peptide hormone receptors are frequently overexpressed on endocrine tumor cells and can be specifically targeted by various anti-tumor peptide analogs. The present study carried out on mouse pheochromocytoma cells (MPCs) and a more aggressive mouse tumor tissue-derived (MTT) cell line revealed that these cells are characterized by pronounced expression of the somatostatin receptor 2 (sst2), growth hormone-releasing hormone (GHRH) receptor and the luteinizing hormone-releasing hormone (LHRH) receptor. We further demonstrated significant anti-tumor effects mediated by cytotoxic somatostatin analogs, AN-162 and AN-238, by LHRH antagonist, Cetrorelix, by the cytotoxic LHRH analog, AN-152, and by recently developed GHRH antagonist, MIA-602, on MPC and for AN-152 and MIA-602 on MTT cells. Studies of novel anti-tumor compounds on these mouse cell lines serve as an important basis for mouse models of metastatic pheochromocytoma, which we are currently establishing.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume371
Issue number1-2
DOIs
StatePublished - May 22 2013

Keywords

  • Peptide analogs
  • Pheochromocytoma
  • Targeted tumor therapy

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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    Ziegler, C. G., Ullrich, M., Schally, A. V., Bergmann, R., Pietzsch, J., Gebauer, L., Gondek, K., Qin, N., Pacak, K., Ehrhart-Bornstein, M., Eisenhofer, G., & Bornstein, S. R. (2013). Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells. Molecular and Cellular Endocrinology, 371(1-2), 189-194. https://doi.org/10.1016/j.mce.2012.12.011