Anti-lymphocyte therapy successfully controls late "cholestatic" rejection in pediatric liver transplant recipients

N. Kerkar, R. A. Morotti, K. Iyer, R. Arnon, T. Miloh, M. Sturdevant, F. Suchy, S. Florman, S. Emre

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Rejection is independently associated with liver graft loss in children. We report the successful rescue of grafts using ATG+/-OKT3 in late rejection associated with cholestasis. Retrospective chart review was performed after IRB approval. Between 2003 and 2010, 14 pediatric liver transplant recipients received anti-lymphocyte treatment for "cholestatic" rejection. Median age at transplantation was 12.7yr (range 0.9-23.4), eight were boys, and immunosuppression was tacrolimus based. Median time from transplantation to rejection was fiveyr (range 1.1-10.5). Median peak total bilirubin was 11.1mg/dL (range 1.4-18). All showed moderate to severe acute rejection and hepatocellular cholestasis on histology. ATG/OKT3 was started as first-line therapy in six and in the remaining eight as second-line therapy after failure of pulse steroids. Thirteen responded with normalization of aminotransferases and bilirubin, median time 16wk (range 7-112); one non-adherent recipient has still not achieved normal graft function at last follow-up. Patient survival is 100%, with no re-transplantation and no post-transplant lymphoproliferative disease, median follow-up 2.9yr (range 1.1-7.2). Cholestasis associated with acute rejection occurring late after liver transplantation may herald steroid resistance. First-line therapy with anti-lymphocyte preparations, prophylactic anti-microbial therapy, and close monitoring allow excellent rates of patient and graft survival.

Original languageEnglish (US)
Pages (from-to)E584-E591
JournalClinical Transplantation
Volume25
Issue number6
DOIs
StatePublished - Nov 2011
Externally publishedYes

Keywords

  • Adolescents
  • Anti-lymphocyte treatment
  • Cholestasis
  • Graft survival
  • Non-adherence

ASJC Scopus subject areas

  • Transplantation

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