Anti-inflammatory nutrition as a pharmacological approach to treat obesity

Barry Sears, Camillo Ricordi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.

Original languageEnglish
Article number431985
JournalJournal of Obesity
Volume2011
DOIs
StatePublished - Jan 1 2011

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Anti-Inflammatory Agents
Obesity
Pharmacology
Diet
Eicosanoids
Toll-Like Receptors
Arachidonic Acid
Comorbidity
Immune System
Transcription Factors
Hormones
Gene Expression
Food
Genes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Anti-inflammatory nutrition as a pharmacological approach to treat obesity. / Sears, Barry; Ricordi, Camillo.

In: Journal of Obesity, Vol. 2011, 431985, 01.01.2011.

Research output: Contribution to journalArticle

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