Anti-inflammatory activity of extracts and isolated alkaloidal fraction from leaves of Bryophyllum pinnatum

Randhir Gupta, M. Lohani, S. Arora, Ashish K. Rehni, Ratandeep Chauhan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The water, petroleum ether, chloroform, acetone and methanolic extracts and the alkaloidal fraction of methanolic extract from the leaves of Bryophyllum pinnatum were evaluated for anti-inflammatory activity against carrageenan induced rat paw edema, formalin induced paw edema, changes in lysosomal enzyme (cathepsin-d) levels and DPPH free radical scavenging activity. The methanolic extract of Bryophyllum pinnatum leaves and the alkaloidal fraction of methanolic extract showed significant (P<0.001) antiinflammatory activity in all (early, intermediate and late) stages of inflammation against carrageenan induced paw edema, significant (p<0.01) reversal of changes in lysosomal enzyme (cathepsin-d) levels during formalin induced paw edema and significant DPPH free radical scavenging activity (p<0.001 for methanolic extract and p<0.05 for alkaloidal fraction). Thus the alkaloidal fraction may be majorly responsible for the anti-inflammatory activity of the methanol extract and further quantitative separation and activities studies may help isolate an anti-inflammatory alkaloid compound from the leaves.

Original languageEnglish (US)
Pages (from-to)873-886
Number of pages14
JournalPharmacologyonline
Volume2
StatePublished - 2009
Externally publishedYes

Keywords

  • Anti-inflammatory activity
  • Bryophyllum pinnatum
  • Carrageenan
  • Edema, Lysosomal enzymes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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