Anti-cataleptic effects of clozapine, but not olanzapine and quetiapine, on SCH 23390- or raclopride-induced catalepsy in rats

Jenny Ahlqvist, Ruben Isacson, Claes Wahlestedt, Peter Salmi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The present study investigated potential anti-cataleptic properties of the prototype atypical antipsychotic clozapine and two newly developed atypical antipsychotics, olanzapine and quetiapine, which are structurally related and display similar pharmacological profiles to clozapine. Clozapine (2.5 mg kg-1, s.c.), but not olanzapine (2.0 mg kg-1, s.c.) and quetiapine (20.0 mg kg-1, s.c.), blocked catalepsy induced either by the dopamine D1/5 receptor antagonist SCH 23390 (50.0 μg kg-1, s.c) or the selective dopamine D2/3 receptor antagonist raclopride (4.0 mg kg-1, s.c.). Such findings are consistent with the beneficial effects of clozapine in the management of drug-induced psychosis in parkinsonian patients, and suggest that neither olanzapine nor quetiapine may be a safe alternative to clozapine in this field. Furthermore, the results indicate that clozapine has a unique pharmacological profile that distinguishes it from olanzapine and quetiapine. The mechanisms underlying anti-cataleptic or anti-parkinsonian properties of clozapine are unclear but may be related to dopamine D1 receptor agonism of clozapine.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume13
Issue number3
DOIs
StatePublished - May 2003
Externally publishedYes

Keywords

  • Atypical antipsychotics
  • Catalepsy
  • Clozapine
  • Olanzapine
  • Parkinson's disease
  • Quetiapine

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

Fingerprint Dive into the research topics of 'Anti-cataleptic effects of clozapine, but not olanzapine and quetiapine, on SCH 23390- or raclopride-induced catalepsy in rats'. Together they form a unique fingerprint.

  • Cite this