Anthracycline cardiotoxicity in long-term survivors of childhood cancer

Rebecca E. Scully, Steven E. Lipshultz

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Anthracycline chemotherapy is a widely-used and effective treatment for a wide spectrum of childhood cancers. Its use is limited by associated progressive and clinically significant cardiotoxic effects. Onset can be acute, early, or late. While acute onset is rare, long-term survivors have significantly elevated rates of cardiac morbidity and mortality. Major complications include cardiomyopathy, coronary artery disease, and atherosclerosis. Means of prevention and treatment continue to be explored including limiting cumulative anthracycline dose, controlling the rate of administration, and using liposomal preparations and novel anthracycline analogues. Dexrazoxane prior to anthracycline chemotherapy has been shown to significantly lower rates of elevated serum cardiac troponin levels, a marker of myocyte injury, indicating a cardioprotective effect. Pilot studies indicate that exercise interventions may also be beneficial in long-term survivors with cardiac damage. Support and study of this population to decrease the morbidity and morality associated with anthracycline-induced cardiotoxicity is indicated in a time sensitive fashion.

Original languageEnglish (US)
Pages (from-to)122-128
Number of pages7
JournalCardiovascular Toxicology
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2007

Keywords

  • Anthracyclines
  • Cardiomyopathy
  • Cardiotoxicity
  • Childhood cancer
  • Survivorship
  • Treatment effects

ASJC Scopus subject areas

  • Toxicology
  • Cardiology and Cardiovascular Medicine

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