Abstract
Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.
| Translated title of the contribution | Anthology of the first clinical studies with hypothalamic hormones: The story of a successful international collaboration |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 89-100 |
| Number of pages | 12 |
| Journal | Gaceta medica de Mexico |
| Volume | 138 |
| Issue number | 1 |
| State | Published - Mar 14 2002 |
| Externally published | Yes |
Keywords
- Clinical trials
- Hypothalamic-releasing hormones
- LH-RH
- LH-RH analogs
- TRH
ASJC Scopus subject areas
- Medicine(all)