Antología de los primeros estudios clínicos con hormonas hipotalámicas

Relato de una exitosa colaboración internacional

Translated title of the contribution: Anthology of the first clinical studies with hypothalamic hormones: The story of a successful international collaboration

Andrew V Schally, Carlos Gual

Research output: Contribution to journalArticle

Abstract

Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.

Original languageSpanish
Pages (from-to)89-100
Number of pages12
JournalGaceta Medica de Mexico
Volume138
Issue number1
StatePublished - Mar 14 2002
Externally publishedYes

Fingerprint

Hypothalamic Hormones
Gonadotropin-Releasing Hormone
Thyrotropin-Releasing Hormone
Thyrotropin
Mexico
Swine
Pituitary Hormone-Releasing Hormones
Hormone Antagonists
Clinical Studies
Clinical Medicine
Hypothyroidism
Gonadotropins
Steroids
Clinical Trials

Keywords

  • Clinical trials
  • Hypothalamic-releasing hormones
  • LH-RH
  • LH-RH analogs
  • TRH

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antología de los primeros estudios clínicos con hormonas hipotalámicas : Relato de una exitosa colaboración internacional. / Schally, Andrew V; Gual, Carlos.

In: Gaceta Medica de Mexico, Vol. 138, No. 1, 14.03.2002, p. 89-100.

Research output: Contribution to journalArticle

@article{77458fc70cf8468faf6529903929f267,
title = "Antolog{\'i}a de los primeros estudios cl{\'i}nicos con hormonas hipotal{\'a}micas: Relato de una exitosa colaboraci{\'o}n internacional",
abstract = "Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.",
keywords = "Clinical trials, Hypothalamic-releasing hormones, LH-RH, LH-RH analogs, TRH",
author = "Schally, {Andrew V} and Carlos Gual",
year = "2002",
month = "3",
day = "14",
language = "Spanish",
volume = "138",
pages = "89--100",
journal = "Gaceta Medica de Mexico",
issn = "0016-3813",
publisher = "Academia Nacional de Medicina",
number = "1",

}

TY - JOUR

T1 - Antología de los primeros estudios clínicos con hormonas hipotalámicas

T2 - Relato de una exitosa colaboración internacional

AU - Schally, Andrew V

AU - Gual, Carlos

PY - 2002/3/14

Y1 - 2002/3/14

N2 - Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.

AB - Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.

KW - Clinical trials

KW - Hypothalamic-releasing hormones

KW - LH-RH

KW - LH-RH analogs

KW - TRH

UR - http://www.scopus.com/inward/record.url?scp=17144450637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144450637&partnerID=8YFLogxK

M3 - Article

VL - 138

SP - 89

EP - 100

JO - Gaceta Medica de Mexico

JF - Gaceta Medica de Mexico

SN - 0016-3813

IS - 1

ER -