Abstract
Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.
| Original language | Spanish |
|---|---|
| Pages (from-to) | 89-100 |
| Number of pages | 12 |
| Journal | Gaceta Medica de Mexico |
| Volume | 138 |
| Issue number | 1 |
| State | Published - Mar 14 2002 |
| Externally published | Yes |
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Keywords
- Clinical trials
- Hypothalamic-releasing hormones
- LH-RH
- LH-RH analogs
- TRH
ASJC Scopus subject areas
- Medicine(all)
Cite this
Antología de los primeros estudios clínicos con hormonas hipotalámicas : Relato de una exitosa colaboración internacional. / Schally, Andrew V; Gual, Carlos.
In: Gaceta Medica de Mexico, Vol. 138, No. 1, 14.03.2002, p. 89-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antología de los primeros estudios clínicos con hormonas hipotalámicas
T2 - Relato de una exitosa colaboración internacional
AU - Schally, Andrew V
AU - Gual, Carlos
PY - 2002/3/14
Y1 - 2002/3/14
N2 - Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.
AB - Our early pioneering clinical trials in Mexico with natural and synthetic thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) also known as gonadotropin releasing hormone (Gn-RH), were reviewed. Highly purified TRH of porcine origin was shown to stimulate Thyrotropin (TSH) release in hypothyroid cretins. Subsequent tests with synthetic TRH also demonstrated significant increases in plasma TSH in normal men and women as well as in patients with primary hypothyroidism and other endocrine disorders. Even more extensive clinical studies were carried out with highly purified natural porcine LH-RH. Subjects with normal basal serum levels of gonadotropins, low levels (men and women pretreated with steroids) and high levels (e.g. post menopausal women) all reponded to LH-RH with a release of LH and FSH. The results of these early studies with the natural LH-RH were confirmed by the use of synthetic LH-RH. These investigations made in Mexico with TRH and LH-RH preceded all other clinical studies by a wide margin. Subsequently various clinical investigations with LH-RH agonists and antagonists were also carried out. All these studies played a major role in introducing hypothalamic-releasing hormones into clinical medicine.
KW - Clinical trials
KW - Hypothalamic-releasing hormones
KW - LH-RH
KW - LH-RH analogs
KW - TRH
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UR - http://www.scopus.com/inward/citedby.url?scp=17144450637&partnerID=8YFLogxK
M3 - Article
VL - 138
SP - 89
EP - 100
JO - Gaceta Medica de Mexico
JF - Gaceta Medica de Mexico
SN - 0016-3813
IS - 1
ER -