Anterior ischemic optic neuropathy in c hurg-s trauss syndrome

J. C. Kattah, G. A. Chrousos, P. A. Katz, B. Mc Casland, M. P. Kolsky

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


A patient with a history of chronic rhinitis, sinusitis, and bronchial asthma developed a unilateral anterior ischemic optic neuropathy and a mild sensory motor neuropathy as the initial manifestation of systemic vasculitis. We made a probable diagnosis of Churg-Strauss syndrome. Fluorescein angiography showed delayed choroidal perfusion in both eyes. Marked eosinophilia, increased sedimentation rate, and elevated perinuclear anti- neutrophil cytoplasmic antibody and anti-myeloperoxidase antibody titers were the main laboratory abnormalities that supported this diagnosis. Therapy with high-dose methylprednisolone and cyclophosphamide may have preserved vision in the better seeing eye, improved its choroidal circulation, and reversed the laboratory abnormalities except for a mild persistent eosinophilia. The neuropathy is gradually improving.

Original languageEnglish (US)
Pages (from-to)2200-2202
Number of pages3
Issue number11
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Clinical Neurology


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