Anterior ciliary sclerotomy: Effect on corneal topography, globe integrity, and the role of a novel antifibrotic gel

Peggy Lamar, Viviana Femandez, Fabrice Manns, Sander Dubovy, Stanley Zipper, Samith Sandadi, Natsushi Nakagawa, Marc Weiser, François Malecaze, Jean Mane Parel

Research output: Contribution to journalArticle

Abstract

To (1) quantify changes in corneal topography induced by radial anterior sclerostomy for restoring accommodation and, (2) assess safety and ant fibrosis activity of cross-linked sodium hyaluronic acid (cSHA) based gels in ACS procedures. Methods (ex-vivo study): 6 fresh human Eye-Bank eyes were used. A 15% Dextran solution was injected in the anterior chamber and the vitreous cavity, the corneal epithelium was removed by scraping, and the whole eye was immersed in 15% Dextran solution until corneal thickness reached a physiological value. The conjunctiva and tenon capsule were removed and the eye was mounted on a custom-made holder. Preoperative corneal topography was measured with a PAR corneal topography system. Five to eight 3mm-long linear equidistant anterior radial incisions starting from the limbus were performed in the sclera at 90% depth with a diamond blade. Postoperative corneal topography was measured. The files providing the pre and postoperative tangential curvature along meridians separated by 5 degrees were exported. The axial curvature along the 0 and 90-degree meridians before and after surgery were compared. Methods (in-vivo study): Of 24 rabbits, 4 were operated following Thornton’s (90% depth incision) and 20 following Fukasaku’s (100% depth) techniques (total peritomy, four 4mm long radial scleral incisions starting 0.5 mm from the limbus).

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4611
Issue number1
DOIs
StatePublished - Jun 13 2002

Keywords

  • Accommodation
  • Anterior ciliary sclerotomy
  • Corneal topography
  • Hydrogels
  • Implants

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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