Abstract
To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24-5.32] and 5.83 [95% CI, 3.17- 10.70], respectively) if antimicrobials had been taken during the previous 15-28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.
| Original language | English |
|---|---|
| Pages (from-to) | 63-68 |
| Number of pages | 6 |
| Journal | Clinical Infectious Diseases |
| Volume | 25 |
| Issue number | 1 |
| State | Published - Jul 24 1997 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women. / Smith, H. S.; Hughes, J. P.; Hooton, Thomas; Roberts, P.; Scholes, D.; Stergachis, A.; Stapleton, A.; Stamm, W. E.
In: Clinical Infectious Diseases, Vol. 25, No. 1, 24.07.1997, p. 63-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women
AU - Smith, H. S.
AU - Hughes, J. P.
AU - Hooton, Thomas
AU - Roberts, P.
AU - Scholes, D.
AU - Stergachis, A.
AU - Stapleton, A.
AU - Stamm, W. E.
PY - 1997/7/24
Y1 - 1997/7/24
N2 - To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24-5.32] and 5.83 [95% CI, 3.17- 10.70], respectively) if antimicrobials had been taken during the previous 15-28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.
AB - To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24-5.32] and 5.83 [95% CI, 3.17- 10.70], respectively) if antimicrobials had been taken during the previous 15-28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.
UR - http://www.scopus.com/inward/record.url?scp=0030832238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030832238&partnerID=8YFLogxK
M3 - Article
C2 - 9243034
AN - SCOPUS:0030832238
VL - 25
SP - 63
EP - 68
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 1
ER -