TY - JOUR
T1 - Anoxia tolerant animals from a neurobiological perspective
AU - Lutz, Peter L.
AU - Nilsson, Göran E.
AU - Peréz-Pinzón, Miguel A.
N1 - Funding Information:
We thank the Florida Atlantic University Foundation, the Swedish Council for Forestry and Agricultural Research, the Swedish Natural Science Re. search Council, and the Magn. Bergvall Foundation for financial support.
PY - 1996
Y1 - 1996
N2 - This paper discusses the mechanisms for brain anoxia survival seen in crucian carp (Carassius carassius) and a few species of freshwater turtle (Chrysemys and Trachemys species). Comparisons are made with the hypoxic tolerant mammalian neonate brain. In the anoxic tolerant species the basic strategy for anoxia survival appears to be the maintenance of ion gradients, and thereby the avoidance of anoxic depolarization. Important facilitating factors involve having huge glycogen stores, increased blood supply to the brain, the suppression of electrical activity, increased release of inhibitory neuromodulators and neurotransmitters, upregulation of inhibitory neuroreceptors, the down-regulation of excitatory ion conductance and the down-regulation of Ca2+ channels. By contrast, for the mammalian neonate the most important causes of its increased hypoxia tolerance may be just simple consequences of the comparatively undifferentiated state of the brain of the newborn, with its lower energy requirements, slower decline in ATP and lower excitability levels acting to delay depolarization.
AB - This paper discusses the mechanisms for brain anoxia survival seen in crucian carp (Carassius carassius) and a few species of freshwater turtle (Chrysemys and Trachemys species). Comparisons are made with the hypoxic tolerant mammalian neonate brain. In the anoxic tolerant species the basic strategy for anoxia survival appears to be the maintenance of ion gradients, and thereby the avoidance of anoxic depolarization. Important facilitating factors involve having huge glycogen stores, increased blood supply to the brain, the suppression of electrical activity, increased release of inhibitory neuromodulators and neurotransmitters, upregulation of inhibitory neuroreceptors, the down-regulation of excitatory ion conductance and the down-regulation of Ca2+ channels. By contrast, for the mammalian neonate the most important causes of its increased hypoxia tolerance may be just simple consequences of the comparatively undifferentiated state of the brain of the newborn, with its lower energy requirements, slower decline in ATP and lower excitability levels acting to delay depolarization.
KW - carp brain
KW - metabolic depression
KW - neonate brain
KW - neurotransmitters
KW - NO
KW - potassium
KW - turtle brain
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U2 - 10.1016/0305-0491(95)02046-2
DO - 10.1016/0305-0491(95)02046-2
M3 - Article
C2 - 8936038
AN - SCOPUS:0029869277
VL - 113
SP - 3
EP - 13
JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
SN - 0305-0491
IS - 1
ER -