Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits

D. M. O'Day, W. S. Head, R. D. Robinson, T. E. Williams, Steven J Gedde

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

After intrastromal injection of a standardized inoculum of Candida albicans blastoconidia in Dutch-belted rabbits, the efficacy of subconjunctival therapy with amphotericin B and miconazole was evaluated using a quantitative isolate recovery technique. The subconjunctival injection of miconazole resulted in the recovery of significantly more viable organisms compared to the number recovered in controls (2,000 μg daily, P < .02; 3,000 μg daily, P < .01, respectively). Amphotericin B, in contrast, in dosages of 500 or 1,500 μg daily, had a significant therapeutic effect (P < .03). The anomalous response to subconjunctival therapy with miconazole seen in this model suggests an effect on host defense mechanisms.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume112
Issue number5
StatePublished - Jan 1 1991
Externally publishedYes

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Miconazole
Keratitis
Candida albicans
Amphotericin B
Rabbits
Injections
Therapeutic Uses
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits. / O'Day, D. M.; Head, W. S.; Robinson, R. D.; Williams, T. E.; Gedde, Steven J.

In: American Journal of Ophthalmology, Vol. 112, No. 5, 01.01.1991, p. 562-566.

Research output: Contribution to journalArticle

O'Day, DM, Head, WS, Robinson, RD, Williams, TE & Gedde, SJ 1991, 'Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits', American Journal of Ophthalmology, vol. 112, no. 5, pp. 562-566.
O'Day, D. M. ; Head, W. S. ; Robinson, R. D. ; Williams, T. E. ; Gedde, Steven J. / Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits. In: American Journal of Ophthalmology. 1991 ; Vol. 112, No. 5. pp. 562-566.
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