Anomalous effect of subconjunctival miconazole on Candida albicans keratitis in rabbits

D. M. O'Day, W. S. Head, R. D. Robinson, T. E. Williams, S. J. Gedde

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

After intrastromal injection of a standardized inoculum of Candida albicans blastoconidia in Dutch-belted rabbits, the efficacy of subconjunctival therapy with amphotericin B and miconazole was evaluated using a quantitative isolate recovery technique. The subconjunctival injection of miconazole resulted in the recovery of significantly more viable organisms compared to the number recovered in controls (2,000 μg daily, P < .02; 3,000 μg daily, P < .01, respectively). Amphotericin B, in contrast, in dosages of 500 or 1,500 μg daily, had a significant therapeutic effect (P < .03). The anomalous response to subconjunctival therapy with miconazole seen in this model suggests an effect on host defense mechanisms.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalAmerican journal of ophthalmology
Volume112
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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