Ankrd11 is a chromatin regulator involved in autism that is essential for neural development

Denis Gallagher, Anastassia Voronova, Mark A. Zander, Gonzalo I. Cancino, Alexa Bramall, Matthew P. Krause, Clemer Abad, Mustafa Tekin, Paul M. Neilsen, David F. Callen, Stephen W. Scherer, Gordon M. Keller, David R. Kaplan, Katherina Walz, Freda D. Miller

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Ankrd11 is a potential chromatin regulator implicated in neural development and autism spectrum disorder (ASD) with no known function in the brain. Here, we show that knockdown of Ankrd11 in developing murine or human cortical neural precursors caused decreased proliferation, reduced neurogenesis, andaberrant neuronal positioning. Similar cellular phenotypes and aberrant ASD-like behaviors were observed in Yoda mice carrying a point mutation inthe Ankrd11 HDAC-binding domain. Consistent with a role for Ankrd11 in histone acetylation, Ankrd11 was associated with chromatin and colocalized with HDAC3, and expression and histone acetylation of Ankrd11 target genes were altered in Yoda neural precursors. Moreover, the Ankrd11 knockdown-mediated decrease in precursor proliferation was rescued by inhibiting histone acetyltransferase activity or expressing HDAC3. Thus, Ankrd11 is a crucial chromatin regulator that controls histone acetylation and gene expression during neural development, thereby providing a likely explanation for its association with cognitive dysfunction and ASD.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalDevelopmental Cell
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2015

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Acetylation
Autistic Disorder
Histones
Chromatin
Histone Acetyltransferases
Neurogenesis
Point Mutation
Gene expression
Brain
Genes
Association reactions
Phenotype
Gene Expression
Autism Spectrum Disorder

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Gallagher, D., Voronova, A., Zander, M. A., Cancino, G. I., Bramall, A., Krause, M. P., ... Miller, F. D. (2015). Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Developmental Cell, 32(1), 31-42. https://doi.org/10.1016/j.devcel.2014.11.031

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. / Gallagher, Denis; Voronova, Anastassia; Zander, Mark A.; Cancino, Gonzalo I.; Bramall, Alexa; Krause, Matthew P.; Abad, Clemer; Tekin, Mustafa; Neilsen, Paul M.; Callen, David F.; Scherer, Stephen W.; Keller, Gordon M.; Kaplan, David R.; Walz, Katherina; Miller, Freda D.

In: Developmental Cell, Vol. 32, No. 1, 01.01.2015, p. 31-42.

Research output: Contribution to journalArticle

Gallagher, D, Voronova, A, Zander, MA, Cancino, GI, Bramall, A, Krause, MP, Abad, C, Tekin, M, Neilsen, PM, Callen, DF, Scherer, SW, Keller, GM, Kaplan, DR, Walz, K & Miller, FD 2015, 'Ankrd11 is a chromatin regulator involved in autism that is essential for neural development', Developmental Cell, vol. 32, no. 1, pp. 31-42. https://doi.org/10.1016/j.devcel.2014.11.031
Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP et al. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Developmental Cell. 2015 Jan 1;32(1):31-42. https://doi.org/10.1016/j.devcel.2014.11.031
Gallagher, Denis ; Voronova, Anastassia ; Zander, Mark A. ; Cancino, Gonzalo I. ; Bramall, Alexa ; Krause, Matthew P. ; Abad, Clemer ; Tekin, Mustafa ; Neilsen, Paul M. ; Callen, David F. ; Scherer, Stephen W. ; Keller, Gordon M. ; Kaplan, David R. ; Walz, Katherina ; Miller, Freda D. / Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. In: Developmental Cell. 2015 ; Vol. 32, No. 1. pp. 31-42.
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