Stroke is the second leading cause of death worldwide. Up to 80% of strokes are ischemic and take place due to occlusion of major cerebral arteries or its branches. The pathophysiology of stroke is multifaceted, involving excitotoxicity and activation of inflammatory pathways leading to disturbances in ion channels, oxidative damage, and apoptosis. Thrombolytics are the only FDA-approved drug for ischemic stroke. In order to study the pathophysiology, development of a reliable and reproducible model of ischemic stroke is of great importance. The ideal animal model is the one which can mimic the features of the pathology. This chapter summarizes the models of ischemic stroke with its advantages and limitations.
- Embolic stroke model
- Middle cerebral artery occlusion
ASJC Scopus subject areas
- Health Professions(all)