Animal models of ischemic stroke

Harpreet Kaur, Deepaneeta Sarmah, Kiran Kalia, Anupom Borah, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stroke is the second leading cause of death worldwide. Up to 80% of strokes are ischemic and take place due to occlusion of major cerebral arteries or its branches. The pathophysiology of stroke is multifaceted, involving excitotoxicity and activation of inflammatory pathways leading to disturbances in ion channels, oxidative damage, and apoptosis. Thrombolytics are the only FDA-approved drug for ischemic stroke. In order to study the pathophysiology, development of a reliable and reproducible model of ischemic stroke is of great importance. The ideal animal model is the one which can mimic the features of the pathology. This chapter summarizes the models of ischemic stroke with its advantages and limitations.

Original languageEnglish (US)
Title of host publicationApplication of Biomedical Engineering in Neuroscience
PublisherSpringer Singapore
Pages41-50
Number of pages10
ISBN (Electronic)9789811371424
ISBN (Print)9789811371417
DOIs
StatePublished - Nov 19 2019

Keywords

  • Craniectomy
  • Embolic stroke model
  • Endothelin-1
  • Middle cerebral artery occlusion
  • Photothrombosis

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Health Professions(all)

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