Animal models of aspergillosis

Guillaume Desoubeaux, Carolyn Cray

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals. The growing importance of this infection over recent decades has created a need for practical and reproducible models of aspergillosis. The use of laboratory animals provides a platform to understand fungal virulence and pathophysiology, assess diagnostic tools, and evaluate new antifungal drugs. In this review, we describe the fungus, various Aspergillus-related diseases in humans and animals and various experimental animal models. Overall, we highlight the advantages and limitations of the animal models, the experimental variables that can affect the course of the disease and the reproducibility of infection, and the critical need for standardization of the species, immunosuppressive drugs, route of infection, and diagnostic criteria to use.

Original languageEnglish (US)
Pages (from-to)109-123
Number of pages15
JournalComparative Medicine
Volume68
Issue number2
StatePublished - Apr 1 2018
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Desoubeaux, G., & Cray, C. (2018). Animal models of aspergillosis. Comparative Medicine, 68(2), 109-123.