Animal models of alcoholic neuropathy: Morphologic, electrophysiologic, and biochemical findings

E. P. Bosch, R. W. Pelham, C. G. Rasool, A. Chatterjee, R. W. Lash, L. Brown, T. L. Munsat, Walter G Bradley

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A chronic high alcohol intake was induced in rats through the use of two procedures: the schedule-induced polydipsia technique and the liquid diet technique. Rats consumed 11-12 g of ethanol per kilogram body weight per day for 16 to 18 weeks. Morphologic evidence of a mild distal axonal neuropathy in the ventral caudal nerve was produced. The red blood cell transketolase levels were normal, indicating that the rats were not deficient in thiamine and suggesting that the axonal degeneration was due to the direct toxic effect of alcohol. Axonal transport studies demonstrated a significant increase in the amount of acetylcholinesterase transported in an orthograde direction in the sciatic nerves of alcohol-exposed rats, and indicated no change in the transport of choline acetyltransferase or in the specific binding of colchicine by neurotubulin.

Original languageEnglish
Pages (from-to)133-144
Number of pages12
JournalMuscle and Nerve
Volume2
Issue number2
DOIs
StatePublished - Nov 27 1979
Externally publishedYes

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Alcoholic Neuropathy
Animal Models
Alcohols
Transketolase
Polydipsia
Axonal Transport
Choline O-Acetyltransferase
Poisons
Thiamine
Colchicine
Sciatic Nerve
Acetylcholinesterase
Appointments and Schedules
Ethanol
Erythrocytes
Body Weight
Diet

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Animal models of alcoholic neuropathy : Morphologic, electrophysiologic, and biochemical findings. / Bosch, E. P.; Pelham, R. W.; Rasool, C. G.; Chatterjee, A.; Lash, R. W.; Brown, L.; Munsat, T. L.; Bradley, Walter G.

In: Muscle and Nerve, Vol. 2, No. 2, 27.11.1979, p. 133-144.

Research output: Contribution to journalArticle

Bosch, EP, Pelham, RW, Rasool, CG, Chatterjee, A, Lash, RW, Brown, L, Munsat, TL & Bradley, WG 1979, 'Animal models of alcoholic neuropathy: Morphologic, electrophysiologic, and biochemical findings', Muscle and Nerve, vol. 2, no. 2, pp. 133-144. https://doi.org/10.1002/mus.880020208
Bosch EP, Pelham RW, Rasool CG, Chatterjee A, Lash RW, Brown L et al. Animal models of alcoholic neuropathy: Morphologic, electrophysiologic, and biochemical findings. Muscle and Nerve. 1979 Nov 27;2(2):133-144. https://doi.org/10.1002/mus.880020208
Bosch, E. P. ; Pelham, R. W. ; Rasool, C. G. ; Chatterjee, A. ; Lash, R. W. ; Brown, L. ; Munsat, T. L. ; Bradley, Walter G. / Animal models of alcoholic neuropathy : Morphologic, electrophysiologic, and biochemical findings. In: Muscle and Nerve. 1979 ; Vol. 2, No. 2. pp. 133-144.
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