Animal models for antineoplastic chemotherapy-induced alopecia

Tongyu C. Wikramanayake, Sonal Choudhary, Lucia M. Mauro, Joaquin J. Jimenez

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the most common and distressing side effects of cancer therapy is chemotherapy-induced alopecia (CIA). Approximately 65% of patients receiving anti-neoplastic therapies experience some degree of alopecia. The study of CIA had been hampered by the lack of suitable animal models; in this regard, the first animal models used to study CIA were impractical and difficult to extrapolate to the humans. In recent years, the development of the young rat models and the mouse model of CIA opened new avenues to the investigation and understanding of the mechanisms of CIA. However, there has been much controversy as to which model is more suitable to study the histopathology and molecular mechanisms of CIA. The young rat model has been employed due to the fact that 100% of the pelage hair follicles are in the growth phase during postnatal morphogenesis, therefore mimicking the human scalp where 90% of the hair follicles are undergoing anagen (active growth phase of the hair cycle) at any given time. In contrast, in the adult mouse and rat models, anagen synchronization needs to be induced by depilation or shaving to mimic the human scalp. These models have been extensively used in the search for protective agents against CIA. In this chapter, we will compare and contrast the different models and review the state-of-the-art findings in terms of animal models and protective agents.

Original languageEnglish (US)
Title of host publicationAnimal Models in Cancer Research and Human Disease
Subtitle of host publicationApplications, Outcomes and Controversies
PublisherNova Science Publishers, Inc.
Pages105-119
Number of pages15
ISBN (Print)9781624175879
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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