Animal model of Fusarium solani keratitis

Richard Forster, Gerbert Rebell

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in 35 to 40% of the animals two weeks later. To produce progressive culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume79
Issue number3
StatePublished - Jan 1 1975

Fingerprint

Keratitis
Fusarium
Ulcer
Animal Models
Fungal Spores
Antifungal Agents
Cornea
Virulence
Adrenal Cortex Hormones
Pathology
Rabbits
Temperature
Infection

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Forster, R., & Rebell, G. (1975). Animal model of Fusarium solani keratitis. American Journal of Ophthalmology, 79(3), 510-515.

Animal model of Fusarium solani keratitis. / Forster, Richard; Rebell, Gerbert.

In: American Journal of Ophthalmology, Vol. 79, No. 3, 01.01.1975, p. 510-515.

Research output: Contribution to journalArticle

Forster, R & Rebell, G 1975, 'Animal model of Fusarium solani keratitis', American Journal of Ophthalmology, vol. 79, no. 3, pp. 510-515.
Forster R, Rebell G. Animal model of Fusarium solani keratitis. American Journal of Ophthalmology. 1975 Jan 1;79(3):510-515.
Forster, Richard ; Rebell, Gerbert. / Animal model of Fusarium solani keratitis. In: American Journal of Ophthalmology. 1975 ; Vol. 79, No. 3. pp. 510-515.
@article{186c1ed604524f708f4c360261cde990,
title = "Animal model of Fusarium solani keratitis",
abstract = "Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in 35 to 40{\%} of the animals two weeks later. To produce progressive culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.",
author = "Richard Forster and Gerbert Rebell",
year = "1975",
month = "1",
day = "1",
language = "English",
volume = "79",
pages = "510--515",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Animal model of Fusarium solani keratitis

AU - Forster, Richard

AU - Rebell, Gerbert

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in 35 to 40% of the animals two weeks later. To produce progressive culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.

AB - Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in 35 to 40% of the animals two weeks later. To produce progressive culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.

UR - http://www.scopus.com/inward/record.url?scp=0016796024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016796024&partnerID=8YFLogxK

M3 - Article

C2 - 804817

AN - SCOPUS:0016796024

VL - 79

SP - 510

EP - 515

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -