@article{9fcf42acfe0e42b180916ed389f507d5,
title = "Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells",
abstract = "Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca2+ transients. Compared to wild type, Ca2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca2+-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca2+ signaling within the central nervous system.",
author = "Rene Barro-Soria and Alejandro Caicedo and Herbert J{\"a}gle and Laura Merkel and Na Zhao and Gabriel Knop and Kaspar Gierke and Andrea Dannullis and Hayo Castrop and Brandst{\"a}tter, {Johann Helmut} and Frank Kirchhoff and Andreas Feigenspan and Olaf Strau{\ss}",
note = "Funding Information: Tg(Rac3-EGFP)JZ58Gsat/Mmcd (Rac3-EGFP) mice were obtained from the Mutant Mouse Regional Resource Center, a NCRR-NIH funded strain repository, and were donated to the MMRRC by the NINDS funded GENSAT BAC transgenic project. Funding Information: The authors thank the excellent technical expertise of Elfriede Eckert (Experimental Ophthalmologe Regensburg) and Bernhard Gess (Institute of Physiology Regensburg).This work has been funded by the Deutsche Forschungsgemeinschaft (DFG) grant SFB699, subprojects B7 (Castrop) and B8 (Strau{\ss}). We acknowledge support from the German Research Foundation (DFG) and the Open Access Publications Fonds of the Charite - Universit{\"a}tsmedizin Berlin.",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41598-019-55380-8",
language = "English (US)",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}