Angiotensin binding sites in bovine and human retinal blood vessels

G. Ferrari-Dileo, E. B. Davis, D. R. Anderson

Research output: Contribution to journalArticle

55 Scopus citations


Blood vessels isolated from bovine and human retinas have sites that specifically bind 3H-angiotensin II (3H-Ag II) with an apparent dissociation constant (Kd) of 14 nM and a capacity of binding (Bmax) of 0.82 pmol/g. The binding sites for 3H-Ag II appear to be influenced by guanine nucleotides (GTP) and cations (Mg2+ and Na+) in a way that resembles angiotensin II receptors in other tissues. The physiologic effect of blood-borne or locally-formed angiotensin II on retinal blood flow remains to be defined.

Original languageEnglish (US)
Pages (from-to)1747-1751
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - Dec 1 1987


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Ferrari-Dileo, G., Davis, E. B., & Anderson, D. R. (1987). Angiotensin binding sites in bovine and human retinal blood vessels. Investigative Ophthalmology and Visual Science, 28(11), 1747-1751.