Angiotensin binding sites in bovine and human retinal blood vessels

G. Ferrari-Dileo, E. B. Davis, D. R. Anderson

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Blood vessels isolated from bovine and human retinas have sites that specifically bind 3H-angiotensin II (3H-Ag II) with an apparent dissociation constant (Kd) of 14 nM and a capacity of binding (Bmax) of 0.82 pmol/g. The binding sites for 3H-Ag II appear to be influenced by guanine nucleotides (GTP) and cations (Mg2+ and Na+) in a way that resembles angiotensin II receptors in other tissues. The physiologic effect of blood-borne or locally-formed angiotensin II on retinal blood flow remains to be defined.

Original languageEnglish (US)
Pages (from-to)1747-1751
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - 1987

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Angiotensin binding sites in bovine and human retinal blood vessels'. Together they form a unique fingerprint.

Cite this