Angiosarcoma of the breast

Stephan A. Vorburger, Yan Xing, Kelly K. Hunt, Gregory E. Lakin, Robert S. Benjamin, Barry W. Feig, Peter W T Pisters, Matthew T. Ballo, Lei Chen, Jonathan Trent, Michael Burgess, Shreyaskumar Patel, Raphael E. Pollock, Janice N. Cormier

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

BACKGROUND. Angiosarcoma of the breast is a rare entity. The objectives of this study were to evaluate prognostic factors and determine outcomes in a large contemporary series of patients. METHODS. Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003. Overall survival (OS) and disease-free survival (DFS) were estimated using the methods of Kaplan and Meier. Multivariate analyses were performed to evaluate prognostic factors. RESULTS. Fifty-five women with angiosarcoma of the breast were identified. The median age was 49.1 years, and the median follow-up time was 3.7 years. The median OS and DFS were 2.96 years and 2.26 years, respectively. For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%. Twenty-three (42%) patients had received prior radiation therapy for the treatment of breast cancer. These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast. Although radiation-naive patients appeared to have had better early DFS and OS, the Kaplan-Meier curves were not statistically different between patients with radiation therapy-associated disease and radiation therapy-naive patients. On multivariate analysis, tumor recurrence (P = 0.006) was the only significant adverse prognostic factor noted for OS. CONCLUSIONS. In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.

Original languageEnglish
Pages (from-to)2682-2688
Number of pages7
JournalCancer
Volume104
Issue number12
DOIs
StatePublished - Dec 15 2005
Externally publishedYes

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Radiotherapy
Hemangiosarcoma
Disease-Free Survival
Survival
Angiosarcoma of the breast
Multivariate Analysis
Radiation
Kaplan-Meier Estimate
Breast Neoplasms
Recurrence
Neoplasms
Therapeutics

Keywords

  • Angiosarcoma
  • Breast cancer
  • Radiation-associated sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Vorburger, S. A., Xing, Y., Hunt, K. K., Lakin, G. E., Benjamin, R. S., Feig, B. W., ... Cormier, J. N. (2005). Angiosarcoma of the breast. Cancer, 104(12), 2682-2688. https://doi.org/10.1002/cncr.21531

Angiosarcoma of the breast. / Vorburger, Stephan A.; Xing, Yan; Hunt, Kelly K.; Lakin, Gregory E.; Benjamin, Robert S.; Feig, Barry W.; Pisters, Peter W T; Ballo, Matthew T.; Chen, Lei; Trent, Jonathan; Burgess, Michael; Patel, Shreyaskumar; Pollock, Raphael E.; Cormier, Janice N.

In: Cancer, Vol. 104, No. 12, 15.12.2005, p. 2682-2688.

Research output: Contribution to journalArticle

Vorburger, SA, Xing, Y, Hunt, KK, Lakin, GE, Benjamin, RS, Feig, BW, Pisters, PWT, Ballo, MT, Chen, L, Trent, J, Burgess, M, Patel, S, Pollock, RE & Cormier, JN 2005, 'Angiosarcoma of the breast', Cancer, vol. 104, no. 12, pp. 2682-2688. https://doi.org/10.1002/cncr.21531
Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW et al. Angiosarcoma of the breast. Cancer. 2005 Dec 15;104(12):2682-2688. https://doi.org/10.1002/cncr.21531
Vorburger, Stephan A. ; Xing, Yan ; Hunt, Kelly K. ; Lakin, Gregory E. ; Benjamin, Robert S. ; Feig, Barry W. ; Pisters, Peter W T ; Ballo, Matthew T. ; Chen, Lei ; Trent, Jonathan ; Burgess, Michael ; Patel, Shreyaskumar ; Pollock, Raphael E. ; Cormier, Janice N. / Angiosarcoma of the breast. In: Cancer. 2005 ; Vol. 104, No. 12. pp. 2682-2688.
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AU - Vorburger, Stephan A.

AU - Xing, Yan

AU - Hunt, Kelly K.

AU - Lakin, Gregory E.

AU - Benjamin, Robert S.

AU - Feig, Barry W.

AU - Pisters, Peter W T

AU - Ballo, Matthew T.

AU - Chen, Lei

AU - Trent, Jonathan

AU - Burgess, Michael

AU - Patel, Shreyaskumar

AU - Pollock, Raphael E.

AU - Cormier, Janice N.

PY - 2005/12/15

Y1 - 2005/12/15

N2 - BACKGROUND. Angiosarcoma of the breast is a rare entity. The objectives of this study were to evaluate prognostic factors and determine outcomes in a large contemporary series of patients. METHODS. Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003. Overall survival (OS) and disease-free survival (DFS) were estimated using the methods of Kaplan and Meier. Multivariate analyses were performed to evaluate prognostic factors. RESULTS. Fifty-five women with angiosarcoma of the breast were identified. The median age was 49.1 years, and the median follow-up time was 3.7 years. The median OS and DFS were 2.96 years and 2.26 years, respectively. For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%. Twenty-three (42%) patients had received prior radiation therapy for the treatment of breast cancer. These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast. Although radiation-naive patients appeared to have had better early DFS and OS, the Kaplan-Meier curves were not statistically different between patients with radiation therapy-associated disease and radiation therapy-naive patients. On multivariate analysis, tumor recurrence (P = 0.006) was the only significant adverse prognostic factor noted for OS. CONCLUSIONS. In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.

AB - BACKGROUND. Angiosarcoma of the breast is a rare entity. The objectives of this study were to evaluate prognostic factors and determine outcomes in a large contemporary series of patients. METHODS. Clinical and pathologic factors were analyzed in all patients with angiosarcoma of the breast treated between 1990 and 2003. Overall survival (OS) and disease-free survival (DFS) were estimated using the methods of Kaplan and Meier. Multivariate analyses were performed to evaluate prognostic factors. RESULTS. Fifty-five women with angiosarcoma of the breast were identified. The median age was 49.1 years, and the median follow-up time was 3.7 years. The median OS and DFS were 2.96 years and 2.26 years, respectively. For the 32 patients with primary angiosarcoma of the breast 5-year OS was 59%. Twenty-three (42%) patients had received prior radiation therapy for the treatment of breast cancer. These patients with radiation therapy-associated angiosarcoma were on average 30 years older and less likely to present with distant metastatic disease than patients presenting with radiation-naive angiosarcoma of the breast. Although radiation-naive patients appeared to have had better early DFS and OS, the Kaplan-Meier curves were not statistically different between patients with radiation therapy-associated disease and radiation therapy-naive patients. On multivariate analysis, tumor recurrence (P = 0.006) was the only significant adverse prognostic factor noted for OS. CONCLUSIONS. In this series of 55 patients with angiosarcoma of the breast, radiation therapy-naive angiosarcomas occurred in younger patients, but they behaved similarly to radiation therapy-associated angiosarcomas.

KW - Angiosarcoma

KW - Breast cancer

KW - Radiation-associated sarcoma

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