Angiomyofibroblastoma of the vulva with sarcomatoms transformation ('angiomyofibrosarcoma')

Gunnlaugur P. Nielsen, Robert H. Young, G. Richard Dickersin, Andrew Rosenberg

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

We report on a locally recurrent vulvar tumor in an 80-year-old woman that we believe represents the first example of malignant transformation of an angiomyofibroblastoma. The tumor was predominantly a typical angiomyofibroblastoma, composed of epithelioid or oval cells with eosinophilic cytoplasm that tended to cluster in small groups and around blood vessels. These areas merged imperceptibly with a high-grade sarcoma that resembled a myxoid malignant fibrous histiocytoma. The tumor cells in the benign areas were diffusely immunoreactive for vimentin; many cells were positive for smooth muscle actin, and focal positivity for muscle actin and desmin was observed. The tumor cells in the sarcomatous areas were diffusely positive for vimentin, but negative for smooth muscle actin, muscle actin, and desmin. No staining for keratin, S-100 protein, or CD34 was noted. Ultrastructural examination of the sarcomatous area showed that the cells had the features of fibroblasts. All previously reported cases of angiomyofibroblastoma have exhibited banal histologic features and have behaved in a benign fashion. This case shows that these tumors may rarely be associated with a malignant component, and the designation 'angiomyofibrosarcoma' may be appropriate in such cases.

Original languageEnglish
Pages (from-to)1104-1108
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number9
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Vulva
Actins
Desmin
Vimentin
Neoplasms
Smooth Muscle
Malignant Fibrous Histiocytoma
Muscles
S100 Proteins
Keratins
Sarcoma
Blood Vessels
Cytoplasm
Fibroblasts
Staining and Labeling

Keywords

  • Angiomyofibroblastoma
  • Angiomyofibrosarcoma
  • Vulva

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Angiomyofibroblastoma of the vulva with sarcomatoms transformation ('angiomyofibrosarcoma'). / Nielsen, Gunnlaugur P.; Young, Robert H.; Dickersin, G. Richard; Rosenberg, Andrew.

In: American Journal of Surgical Pathology, Vol. 21, No. 9, 01.01.1997, p. 1104-1108.

Research output: Contribution to journalArticle

Nielsen, Gunnlaugur P. ; Young, Robert H. ; Dickersin, G. Richard ; Rosenberg, Andrew. / Angiomyofibroblastoma of the vulva with sarcomatoms transformation ('angiomyofibrosarcoma'). In: American Journal of Surgical Pathology. 1997 ; Vol. 21, No. 9. pp. 1104-1108.
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