Angiolipoma of the female breast

Clinicomorphological correlation of 52 cases

Oleksandr Kryvenko, Dhananjay A. Chitale, Eve M. Vanegmond, Nilesh S. Gupta, Daniel Schultz, Min W. Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The authors analyzed 52 cases of female breast angiolipoma (AL). Age distribution was 25 to 80 years of age (56.81 ± 12.78). Most cases showed vascularity below 50%, and 14 cases had vascularity >50%. Cellular and low-vascularity ALs had different clinical and radiological presentations. The mean size was 7.00 ± 3.62 mm for cellular ALs and 19.61 ± 7.58 mm for low-vascularity ALs. In any paucicellular area, the authors could identify a cluster of at least 3 interconnected vessels. The endothelium was mostly flat with uniform, hyperchromatic nuclei, and mitoses and nucleoli were absent. Fibrin thrombi in proliferating capillaries were noted in 96% of cases. Low-vascularity AL can be reliably distinguished on needle core biopsy from other lipomatous and vascular tumors of the breast. Tortuosity and proliferation of capillaries with at least 3 interconnected capillary channels in 1 focus with associated fibrin thrombi constitute a very strong clue for the diagnosis of AL on a breast needle core biopsy. Definite diagnosis of cellular AL is not always feasible because of rare cases with mitotic activity and cellular atypia. Excision is often recommended for cellular AL.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalInternational Journal of Surgical Pathology
Volume19
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

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Angiolipoma
Breast
Large-Core Needle Biopsy
Fibrin
Thrombosis
Age Distribution
Mitosis
Endothelium
Blood Vessels
Breast Neoplasms

Keywords

  • angiolipoma
  • biopsy
  • breast
  • cellular
  • female

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Angiolipoma of the female breast : Clinicomorphological correlation of 52 cases. / Kryvenko, Oleksandr; Chitale, Dhananjay A.; Vanegmond, Eve M.; Gupta, Nilesh S.; Schultz, Daniel; Lee, Min W.

In: International Journal of Surgical Pathology, Vol. 19, No. 1, 02.2011, p. 35-43.

Research output: Contribution to journalArticle

Kryvenko, Oleksandr ; Chitale, Dhananjay A. ; Vanegmond, Eve M. ; Gupta, Nilesh S. ; Schultz, Daniel ; Lee, Min W. / Angiolipoma of the female breast : Clinicomorphological correlation of 52 cases. In: International Journal of Surgical Pathology. 2011 ; Vol. 19, No. 1. pp. 35-43.
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