Angiographic demonstration of atherosclerotic stenosis, arterial spasm, and thrombus formation in an infarct‐related coronary artery

Eduardo J. De Marchena, Richard G. Trohman, Andres R. Palomo, Robert J. Myerburg, Kenneth M. Kessler

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Clinical, angiographic, and pathologic data support the contention that atherosclerosis, platelet aggregation, and coronary vasomotility work in unison to cause coronary thrombosis, which in turn leads to myocardial infarction. A patient is described in whom, 2 months after an acute myocardial infarction, inducible coronary artery spasm and a nonocclusive thrombus were angiographically demonstrated at the site of a minimal atherosclerotic narrowing in the infarction-related vessel. This report, to the best of our knowledge, is the first time that these three pathophysiologic mechanisms have been shown, in vivo, to be occurring concomitantly in an infarct-related vessel. Documentation of the unified occurrence of these phenomena support the current concept of the pathophysiology of myocardial infarction.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalCatheterization and Cardiovascular Diagnosis
Volume15
Issue number3
DOIs
StatePublished - 1988

Keywords

  • coronary spasm
  • coronary stenosis
  • myocardial infarction
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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