Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix

Jie Li, Yan Ping Zhang, Robert Kirsner

Research output: Contribution to journalArticle

414 Citations (Scopus)

Abstract

Angiogenesis is critical to wound repair. Newly formed blood vessels participate in provisional granulation tissue formation and provide nutrition and oxygen to growing tissues. In addition, inflammatory cells require the interaction with and transmigration through the endothelial basement membrane to enter the site of injury. Angiogenesis, in response to tissue injury, is a dynamic process that is highly regulated by signals from both serum and the surrounding extracellular matrix (ECM) environment. Vascular endothelial growth factor, angiopoietin, fibroblast growth factor, and transforming growth factor beta are among those most potent angiogenic cytokines in wound angiogenesis. The cooperative regulation of them is essential for wound repair. Migration of endothelial cells and development of new capillary vessels during wound repair is dependent on not only the cells and cytokines present but also the production and organization of ECM components both in granulation tissue and in endothelial basement membrane. The ECM regulates angiogenesis by providing scaffold support and signaling roles. They also serve as a reservoir and modulator for growth factors. Laminins are the major noncollagenous ECM of endothelial basement membrane. Two newly recognized laminins, 8 and 10, are the major laminins produced by human dermal microvascular endothelial cells. Laminin 10 is highly expressed in blood vessels around skin wounds. Laminin 8 promotes dermal endothelial cell attachment, migration, and tubule formation. Integrins with either beta I or alpha v subunits are the major cellular surface receptors for ECM molecules and mediate the interactions between cells and ECM during wound angiogenesis.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalMicroscopy Research and Technique
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

angiogenesis
Angiogenesis Inducing Agents
laminin
extracellular matrix
animal injuries
growth factors
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Endothelial cells
Repair
Tissue
Granulation
basement membrane
Wounds and Injuries
Blood vessels
matrices
basements
endothelial cells
granulation tissue
blood vessels

Keywords

  • Angiopoietin
  • Extracellular matrix
  • FGF
  • Growth factor
  • Integrin
  • Laminin
  • TGFβ
  • VEGF

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Angiogenesis in wound repair : Angiogenic growth factors and the extracellular matrix. / Li, Jie; Zhang, Yan Ping; Kirsner, Robert.

In: Microscopy Research and Technique, Vol. 60, No. 1, 01.01.2003, p. 107-114.

Research output: Contribution to journalArticle

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