Angiogenesis in normal and neoplastic ovaries

S. Ramakrishnan, I. V. Subramanian, Y. Yokoyama, M. Geller

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Ovarian physiology is intricately connected to hormonally regulated angiogenic response. Recent advances in the post genomic revolution have significantly impacted our understanding of ovarian function. In an angiogenesis perspective, the ovary offers a unique opportunity to unravel the molecular orchestration of blood vessel development and regression under normal conditions. A majority of ovarian cancers develop from the single layer of epithelium surrounding the ovaries. Angiogenesis is critical for the development of ovarian cancer and its peritoneal dissemination. The present review summarizes recent findings on the angiogenic response in neoplastic ovaries and discusses the prospects of using anti-angiogenic approaches to treat ovarian cancer.

Original languageEnglish (US)
Pages (from-to)169-182
Number of pages14
JournalAngiogenesis
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Keywords

  • Anginex
  • Corpus luteum
  • Endostatin
  • Follicle
  • Gene therapy
  • Ovarian cancer
  • Ovary
  • VEGF
  • VEGF-trap

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cancer Research

Cite this

Ramakrishnan, S., Subramanian, I. V., Yokoyama, Y., & Geller, M. (2005). Angiogenesis in normal and neoplastic ovaries. Angiogenesis, 8(2), 169-182. https://doi.org/10.1007/s10456-005-9001-1